PMID: 15348209Sep 7, 2004Paper

Characterization of proteins and fibroblasts on thin inorganic films

Journal of Materials Science. Materials in Medicine
Constantina S Giannoulis, T Desai

Abstract

The ability of biomaterial surfaces to regulate cell behavior requires control over surface chemistry and material microstructure. One of the goals in the development of silicon-based biomedical devices such as biosensors or drug delivery systems is improved biocompatibility which may be achieved through the deposition or adsorption of thin films. In this study, films of single crystal silicon, stoichiometric and low stress silicon nitride, doped and undoped polysilicon, as well as Arg-Gly-Asp (RGD) peptide adsorbed surfaces characterized in terms of protein adsorption or cellular adhesion for a period of four days. Protein adsorption studies using fibrinogen and albumin, two proteins implicated in cellular adhesion and surface activity, reveal that low stress silicon nitride surfaces have a 223%+/-2.50% greater protein adsorption compared to undoped polysilicon surfaces, followed by silicon nitride, unmodified silicon, and doped polysilicon surfaces, respectively. The thickness of the adsorbed albumin and fibrinogen layer on various thin films was measured by ellipsometry and compared to contact angle measurements. The greatest cellular adhesion was observed on undoped polysilicon, followed by unmodified (control) silicon, low...Continue Reading

Citations

Mar 5, 2009·Biomedical Materials·Ikuko Machida-SanoHideo Namiki
Jan 26, 2008·Journal of Materials Science. Materials in Medicine·Johan GustavssonElisabeth Engel
Jan 11, 2013·International Journal of Biomaterials·Ikuko Machida-SanoHideo Namiki
Apr 3, 2014·Lasers in Medical Science·Cagri Kaan AkkanOral Cenk Aktas

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