Characterization of proteins in different subcellular localizations for Escherichia coli K12

Genomics
Qi ZhangLei Yang

Abstract

Knowing the comprehensive knowledge about the protein subcellular localization is an important step to understand the function of the proteins. Recent advances in system biology have allowed us to develop more accurate methods for characterizing the proteins at subcellular localization level. In this study, the analysis method was developed to characterize the topological properties and biological properties of the cytoplasmic proteins, inner membrane proteins, outer membrane proteins and periplasmic proteins in Escherichia coli (E. coli). Statistical significant differences were found in all topological properties and biological properties among proteins in different subcellular localizations. In addition, investigation was carried out to analyze the differences in 20 amino acid compositions for four protein categories. We also found that there were significant differences in all of the 20 amino acid compositions. These findings may be helpful for understanding the comprehensive relationship between protein subcellular localization and biological function.

References

Jan 7, 1978·Journal of Theoretical Biology·R R Laxton
Apr 9, 1999·Protein Engineering·K C Chou, D W Elrod
Dec 11, 1999·Nucleic Acids Research·A Bairoch, R Apweiler
Jun 1, 2000·Advances in Protein Chemistry·K Nakai
Oct 26, 2000·Trends in Genetics : TIG·A DrawidM Gerstein
May 3, 2001·Nature·H JeongZ N Oltvai
Mar 27, 2002·Genes & Development·Anuj KumarMichael Snyder
Aug 15, 2002·Trends in Genetics : TIG·Laurence D Hurst
Aug 21, 2002·The Journal of Biological Chemistry·Kuo-Chen Chou, Yu-Dong Cai
Dec 10, 2002·Proteins·Guo-Ping Zhou, Kutbuddin Doctor
Oct 17, 2003·Nature·Won-Ki HuhErin K O'Shea
Nov 19, 2003·Biochemical and Biophysical Research Communications·Kuo-Chen Chou, Yu-Dong Cai
Dec 12, 2003·Bioinformatics·Chen-Shan Chin, Manoj Pratim Samanta
Feb 13, 2004·Bioinformatics·N PrzuljI Jurisica
Jul 3, 2004·Genome Research·Stefan Wuchty
Jan 4, 2005·Proteomics·Stefan Wuchty, Eivind Almaas
Aug 11, 2006·Genome Research·Michael SeringhausMark Gerstein
Aug 19, 2007·Analytical Biochemistry·Kuo-Chen Chou, Hong-Bin Shen
Oct 9, 2007·Nature Biotechnology·Muhammed A YildirimMarc Vidal
Nov 22, 2008·Biochemical Society Transactions·Attila GursoyRuth Nussinov
Apr 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yuri I WolfDavid J Lipman
May 20, 2009·Molecular BioSystems·Yih-Chii HwangHsuan-Cheng Huang
Dec 9, 2010·BMC Bioinformatics·Gaurav Kumar, Shoba Ranganathan
Dec 21, 2010·Journal of Theoretical Biology·Kuo-Chen Chou
Jul 4, 2012·Methods : a Companion to Methods in Enzymology·Max KotlyarIgor Jurisica
Mar 29, 2013·Molecular BioSystems·Kuo-Chen Chou

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