Characterization of Pseudomonas aeruginosa with discrepant carbapenem susceptibility profile

Annals of Clinical Microbiology and Antimicrobials
Agila Kumari PragasamBalaji Veeraraghavan

Abstract

Pseudomonas aeruginosa is the most common nosocomial pathogen, notorious for its multidrug resistance and causes life threatening infections. Carbapenems were considered as the last resort of drugs for the treatment of multi drug resistant P. aeruginosa infections. The emergence of resistance to carbapenems limits its use for treatment. Unlike other organisms, in P. aeruginosa intrinsic/chromosomal mediated resistance mechanisms plays a major role for carbapenem resistance rather than the carbapenemases. Carbapenemase producing organisms becomes resistant to both imipenem and meropenem. However, in our clinical settings, we have observed rare carbapenem resistant phenotypes such as imipenem resistant but meropenem susceptible (IRMS) and meropenem resistant but imipenem susceptible (MRIS) phenotypes. Thus we have chosen these rare phenotypes to look for the respective resistance mechanisms by phenotypic and molecular methods. From this study we found that, IRMS is primarily due to the mutations across various regions in the loops of oprD gene and MRIS is due to the over expression of mexAB efflux pumps. This study results confirms that, this rare phenotypes are due to the intrinsic/chromosomal mediated mechanisms, which occurred...Continue Reading

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Citations

Jun 4, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Annalisa De RosaFrank Günther
Mar 13, 2020·The Journal of Antimicrobial Chemotherapy·Clémence MassipHélène Guet-Revillet
Nov 16, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jinhui LiHongbin Song
Oct 4, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Rajeev SomanBalaji Veeraraghavan
Aug 21, 2020·Antimicrobial Agents and Chemotherapy·Burcu IslerDavid L Paterson
Nov 16, 2018·Indian Journal of Medical Microbiology·Agila Kumari PragasamKeith S Kaye
Feb 22, 2021·Indian Journal of Medical Microbiology·Manish Manrai Gaurab
Nov 17, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Arti NegiKashi Nath Prasad

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Methods Mentioned

BETA
PCR

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