Characterization of purine receptors in mouse thoracic aorta

Journal of Cardiovascular Pharmacology
Jean-Louis Bény

Abstract

The contracting and relaxing effects of purines and UTP were investigated on rings of mouse thoracic aorta in vitro. UTP, ATP gamma S, and alpha-beta-Methyleneadenosine 5'triphosphate contracted rings with and without endothelium. On the contrary, adenosine, AMP, ADP, ATP, and 2-(methylthio)adenosine 5'-diphosphate had no effect on relaxed rings. When rings were tonically contracted by U46619 a thromboxane A2 analogue, ATP, ADP, ATP gamma S, 2-(methylthio)adenosine 5'-diphosphate, and UTP caused endothelium-dependent but not independent relaxations.I conclude that ATP acts on P2Y2 and P2Y1 receptors on the endothelial cells to cause endothelium-dependent relaxation. In this tissue, the relaxing effect of ATP dominates by endothelium-dependent ways when aorta rings are contracted by a stable thromboxane A2 analog. However receptors mediating contraction in response to purines and pyrimidines are present on smooth muscle cells. Indeed, the stimulation of P2Y receptors by UTP as well as the activation of P2X family receptors by ATP gamma S causes a contraction. The potential contractile effect of ATP seems masked by its hydrolysis by ectonucleotidases.

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Citations

Jul 30, 2010·American Journal of Physiology. Cell Physiology·Yuka SumiWolfgang G Junger
Jul 6, 2005·British Journal of Pharmacology·Pieter-Jan D F GunsHidde Bult
May 26, 2015·Autonomic Neuroscience : Basic & Clinical·Vera Ralevic, William R Dunn
Jan 16, 2007·Circulation Research·Brant E IsaksonBrian R Duling
Jan 13, 2006·The Journal of Pharmacology and Experimental Therapeutics·Courtney P JudkinsGrant R Drummond
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Aug 31, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Florian AlonsoJacques-Antoine Haefliger
Oct 28, 2008·American Journal of Physiology. Heart and Circulatory Physiology·François-Xavier BoittinJean-Louis Bény
Mar 27, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Erika M BoermanSteven S Segal

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