PMID: 7527125Jul 1, 1994Paper

Characterization of putative small nuclear RNAs from Giardia lamblia

Molecular and Biochemical Parasitology
X H NiuN Agabian

Abstract

Small nuclear RNAs (snRNAs), which have roles in RNA metabolism, have been found in all eukaryotic cells. Candidate snRNAs were identified in the primitive protozoan parasite, Giardia lamblia, by either immunoprecipitation of total RNA with antiserum directed against the 2,2,7-trimethylguanosine cap structure characteristic of snRNAs or by Northern hybridization with oligonucleotide probes complementary to snRNA consensus sequences. Isolated putative snRNAs include eight 2,2,7-trimethylguanosine-capped species: RNAs A through H, and one non-2,2,7-trimethylguanosine-capped species: RNA J. Single copy genes encoding RNA D, RNA H and RNA J were cloned and sequenced, and the 5' end of each RNA was determined by primer extension analysis. Certain characteristics suggest tentative identification of these Giardia RNAs as nucleolar RNAs with possible roles in rRNA processing.

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Citations

Mar 25, 2000·International Journal for Parasitology·R D Adam
Jan 23, 1999·Current Opinion in Genetics & Development·J M Logsdon
Jan 1, 1996·Nucleic Acids Research·J Gu, R Reddy
Oct 30, 2008·Nucleic Acids Research·Augusto Simoes-BarbosaPatricia J Johnson
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Dec 2, 2008·PLoS Pathogens·Ashesh A Saraiya, Ching C Wang
Jul 21, 2009·Trends in Parasitology·Nikolay G Kolev, Elisabetta Ullu
Jul 11, 2012·Comparative and Functional Genomics·Rosemary JagusAllen R Place
Feb 15, 2005·Biochemical and Biophysical Research Communications·Cheng-Yong YangLiang-Hu Qu
Jul 28, 2005·The Journal of Biological Chemistry·Stéphane Hausmann, Stewart Shuman
Nov 20, 2016·Parasitology Research·Vanessa Gómez, Moisés Wasserman
Nov 24, 2004·The Journal of Biological Chemistry·Stéphane HausmannStewart Shuman
Feb 13, 2001·Protein Expression and Purification·S GhoshD Chattopadhyay

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