PMID: 6406907Jun 9, 1983Paper

Characterization of rat hypothalamic growth hormone-releasing factor

Nature
J SpiessW Vale

Abstract

The importance of the hypothalamus in the regulation of growth hormone (GH) secretion from the adenohypophysis has been supported by experimental and clinical evidence. It has been observed that GH secretion is in part controlled by hypothalamic GH release-inhibiting factors, two forms of which, somatostatin-14 (ref. 5) and somatostatin-28 (refs 6-9), have been characterized. Peptides with GH-releasing activity were recently purified from two human pancreatic tumours of acromegalic patients and characterized. Synthetic versions of these human pancreatic tumour GH-releasing factors (hpGRFs) were found to be potent GH secretagogues in vitro and in vivo and to exhibit actions and interactions similar to those observed with partially purified hypothalamic GRF. GH-releasing peptides have been purified from hypothalami of various species but the structure of natural hypothalamic GRF has not yet been reported. We now describe the purification, sequence analysis and synthesis of a 43-residue polypeptide isolated from rat hypothalamic extracts on the basis of its ability to stimulate GH secretion from cultured rat adenohypophyseal cells. The native polypeptide and its synthetic replicate do not differ significantly in their biological p...Continue Reading

References

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Citations

Jan 1, 1990·The Journal of Experimental Zoology. Supplement : Published Under Auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry·N M Sherwood, D B Parker
Jan 1, 1987·Psychopharmacology·P MonteleoneL Steardo
Jan 1, 1985·Acta neurochirurgica·M O ThornerJ L Thominet
Aug 5, 1985·Brain Research·T ImakiN Ling
Dec 10, 1986·Brain Research·S DaikokuI Nagatsu
Apr 29, 1987·European Journal of Pharmacology·Y MurakamiH Imura
Jan 1, 1988·Life Sciences·C C ChaoL S Frawley
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·J AbuchamS Reichlin
Jan 1, 1988·Molecular Aspects of Medicine·M Wallis
Aug 17, 1987·Regulatory Peptides·F J Vaccarino, K E Buckenham
Jul 31, 1992·Biochimica Et Biophysica Acta·J BongersE P Heimer

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