Characterization of reactions after transfusion of cellular blood components that are white cell reduced before storage

Transfusion
I FederowiczK C Anderson

Abstract

During the storage of cellular components before transfusion, cytokines that may mediate transfusion reactions are released from white cells (WBCs). Adverse effects of transfused cellular blood components therefore depend not only on the number of residual WBCs in blood components, but also on the timing of WBC reduction. Febrile nonhemolytic transfusion reactions (FNHTRs), allergic reactions, and other reactions were characterized in recipients of 4728 units of red cells (RBCs) and 3405 bags of single-donor apheresis platelets (SDAPs), all of which underwent prestorage WBC reduction. To delineate the impact of prestorage versus poststorage WBC reduction of RBCs on transfusion reactions, these results were compared with reactions occurring after the transfusion to similar recipients of 6447 bags of RBCs that underwent poststorage WBC reduction by bedside filtration and 5197 units of SDAPs that underwent prestorage WBC reduction. The levels of interleukin (IL) 1 beta, IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) were measured in a subset of 20 implicated cellular blood components at the time of transfusion reactions and correlated with the duration of storage before transfusion. The incidence of reactions was greater ...Continue Reading

Citations

Jan 30, 2004·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Axel PrussHolger Kiesewetter
Jun 9, 2004·Blood Reviews·Joanna Mary Heal, Neil Blumberg
Dec 20, 1999·Transfusion Medicine Reviews·L A Chambers, J H Herman
Aug 5, 1997·Transfusion Science·I Chin-YeeM S d'Almeida
May 7, 1998·Transfusion Medicine·I Chin-YeeG Moses
Mar 22, 2002·Vox Sanguinis·A ChabanelP Hervé
Dec 2, 2000·Transfusion·K H Western, V Videm
Aug 9, 2001·Transfusion·R YomtovianUNKNOWN Viral Activation Transfusion Study Group
Jan 10, 2003·Transfusion·Hiromichi ArigaUNKNOWN Viral Activation Transfusion Study
Nov 5, 1999·Current Opinion in Hematology·N M Heddle
Jan 16, 2004·Critical Care Medicine·Juliet HoIan H Chin-Yee
Feb 6, 2004·Critical Care Medicine·Gabriel IzbickiMoshe Hersch
Dec 30, 2014·TheScientificWorldJournal·Rejane Santos SousaRaimundo Alves Barrêto
May 24, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Robert LockePaul Fawcett
Jul 5, 2003·Current Medical Research and Opinion·T HatzisV Tzingounis
May 11, 2001·American Journal of Clinical Pathology·J D Sweeney
Feb 17, 2005·Transfusion Medicine·A Da PonteL De Marco
Nov 2, 2006·Transfusion·Alan TinmouthUNKNOWN Canadian Critical Care Trials Group
Dec 17, 2008·Vox Sanguinis·T TasakiY Hoshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.