Characterization of recent H5 subtype avian influenza viruses from US poultry

Avian Pathology : Journal of the W.V.P.A
Chang-Won LeeD L Suarez

Abstract

In the US, the isolation of H5 subtype avian influenza (AI) viruses has been uncommon in commercial chickens and turkeys, although sporadic isolations have been made from the live bird markets or its supply chain since 1986. In 2002, two different outbreaks of H5 AI occurred in commercial chicken or turkey operations. The first occurred in Texas and was identified as a H5N3 subtype AI virus. The second outbreak was caused by a H5N2 virus isolated from a turkey farm in California. In this study we analyzed recent H5 subtype AI viruses from different avian species and different sources in the US. Most recent H5 subtype isolates shared a high sequence identity and phylogenetically assorted into a separate clade from the Pennsylvania/83 lineage isolates. However, no established lineage was found within this clade and the recent H5 subtype isolates seemed to be the result of separate introductions from the wild bird reservoir. The Texas H5N3 isolate shared the lowest homology with the other recent isolates in the haemagglutinin gene and had a unique haemagglutinin cleavage site sequence of REKR/G (other recent isolates have the typical avirulent motif, RETR/G). Furthermore, this isolate had a 28 amino acid deletion in the stalk regi...Continue Reading

References

Mar 14, 1998·Virus Research·M GarcíaM L Perdue
Mar 12, 2002·Virus Research·Hans-Dieter KlenkThorsten Wolff
Jun 18, 2004·Emerging Infectious Diseases·David E SwayneThomas G Ksiazek
Jun 18, 2004·Emerging Infectious Diseases·David L SuarezDennis J Alexander

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Citations

Aug 23, 2006·Virus Genes·Hong-Chao MaZhi-Liang Wang
Mar 16, 2006·Avian Pathology : Journal of the W.V.P.A·Dave Cavanagh
Apr 13, 2007·Clinical Microbiology Reviews·J S Malik PeirisYi Guan
Aug 31, 2007·Journal of Virology·Erica SpackmanTom Deliberto
Mar 20, 2012·PloS One·Ana S González-ReicheDaniel R Perez
May 18, 2006·Journal of Virological Methods·Antoine Danchin, UNKNOWN International INSDC Advisory Committee
Aug 4, 2010·Emerging Infectious Diseases·Pamela J FerroBlanca Lupiani
Oct 1, 2008·Biochemical and Biophysical Research Communications·Akikazu Sakudo, Kazuyoshi Ikuta
Sep 23, 2008·International Journal of Medical Informatics·Sule L MohammedGeorge R Kim
Sep 19, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Deepanker TewariJanice C Pedersen
Oct 8, 2008·Immunological Reviews·David E Swayne, Darrell Kapczynski
Oct 18, 2005·Virology·Alexandra GambaryanAlexander Klimov
Feb 6, 2018·Clinical and Experimental Vaccine Research·Sung J YooYoung S Lyoo
May 24, 2006·Emerging Infectious Diseases·Sunchai PayungpornYong Poovorawan
Aug 19, 2020·Spatial and Spatio-temporal Epidemiology·C Stenkamp-StrahmS Magzamen

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Datasets Mentioned

BETA
AY296064
AY296086
AY300926
AY300951
AY300975
AY300976
AY300999

Methods Mentioned

BETA
glycosylation
PCR

Software Mentioned

PAUP4
PAUP
Clustal V
Megalign
DNASTAR

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