PMID: 8605117Dec 1, 1995Paper

Characterization of regions of chromosomes 12 and 16 involved in nephroblastoma tumorigenesis

Genes, Chromosomes & Cancer
E AustruyC Jeanpierre

Abstract

There are at least three loci involved in Wilms' tumor (WT) tumorigenesis: WT1 in 11p13, WT2 in 11p15.5, and WT3, as yet unmapped. A compilation of cytogenetic data published for 107 WT revealed that deletion of chromosome 16 and duplication of chromosome 12 occur as frequently as the well-documented 11p deletions. Allelic imbalance for chromosomes 16 and 12 was investigated in a series of 28 WT. By use of a large panel of restriction fragment length polymorphisms and (CA)n probes, we demonstrated loss of heterozygosity (LOH) for 16q in seven (25%) of the tumors. The whole length of 16q was involved in six of the tumors. Moreover, consistent with a previous report of 16q13 LOH in a sporadic WT and a constitutional breakpoint with a Beckwith-Wiedemann patient, we map a region of particular interest to between D16S308 and D16S320. The assumption that 16q LOH may be an early event was based on: 1) the detection of 16q LOH in one case of nephroblastomatosis; 2) the presence of a complete (clonal) 16q LOH in a tumor with partial (mosaic) 11p LOH; and 3) 16q LOH as the sole abnormality in one WT. By quantification of chromosome 12 allelic imbalance, we detected duplication in 18% of the total series and in 25% of the sporadic unilate...Continue Reading

References

Jul 15, 1992·Cancer Genetics and Cytogenetics·R M Slater, M M Mannens
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M H LittleP J Smith
Jun 1, 1992·Current Opinion in Genetics & Development·C Junien
Aug 1, 1992·Current Opinion in Genetics & Development·J B Bard
Feb 1, 1986·Analytical Biochemistry·R M Amasino
Jan 1, 1989·Oncology·M VekemansJ P de Chadarevian
Dec 1, 1989·Cancer Genetics and Cytogenetics·H McDowellJ Crampton
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I HenryC Junien
Sep 1, 1988·Cancer Genetics and Cytogenetics·V SolisJ K Cowell
Jan 1, 1985·Cancer Genetics and Cytogenetics·R M SlaterJ F Delemarre
Jan 15, 1985·Cancer Genetics and Cytogenetics·E C DouglassA T Look
Jan 1, 1985·Cytogenetics and Cell Genetics·J SoulieC Nezelof
Jan 1, 1986·Cancer Genetics and Cytogenetics·R M Slater
Jun 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E C DouglassP K Roberson
Mar 1, 1982·Cancer Genetics and Cytogenetics·R M Slater, J de Kraker
Oct 1, 1983·Cancer Genetics and Cytogenetics·Y KanekoH S Maurer
Oct 1, 1993·Genes, Chromosomes & Cancer·K W BrownN J Maitland
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Jul 1, 1994·Nature Genetics·T MoultonB Tycko
Aug 1, 1994·Human Molecular Genetics·W ReikE R Maher
Jan 1, 1993·European Journal of Human Genetics : EJHG·C MoutouC Bonaïti-Pellié
Feb 1, 1993·Nature Genetics·L Y ChaoG F Saunders
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C JeanpierreC Junien
Nov 1, 1995·Cancer Genetics and Cytogenetics·K KaltoftK Thestrup-Pedersen

❮ Previous
Next ❯

Citations

Mar 13, 1998·The Journal of Pathology·T J DorkinD E Neal
Mar 30, 2000·Genes, Chromosomes & Cancer·M SteenmanM Mannens
Sep 11, 2001·Genes, Chromosomes & Cancer·T OzakiB Dockhorn-Dworniczak
Feb 5, 2003·Experimental Cell Research·Nadia El-Guendy, Vivek M Rangnekar
Jul 2, 1998·Cancer Genetics and Cytogenetics·C SandovalS Jayabose
Feb 12, 1999·Cancer Genetics and Cytogenetics·G Z QuM Ehrlich
Nov 22, 2012·European Journal of Human Genetics : EJHG·Bertrand IsidorCédric Le Caignec
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M NemaniA Telerman
Dec 16, 2000·The American Journal of Surgical Pathology·B P RubinA A Renshaw
Sep 15, 2001·Advances in Anatomic Pathology·R A HennigarJ D Grattan-Smith
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·K HelinP Norgaard
Jul 2, 2004·Therapeutic Drug Monitoring·James G Donnelly
Aug 6, 2003·American Journal of Medical Genetics. Part a·Carol E AndersonJean-Pierre de Chadarévian
Sep 15, 1998·The American Journal of Pathology·A K CharlesP J Berry
Aug 2, 2005·Journal of Medical Primatology·S Denise GoensGene B Hubbard
Feb 24, 2006·International Journal of Cancer. Journal International Du Cancer·Magdalena BenetkiewiczJan P Dumanski
Mar 31, 2005·Cancer Letters·Marine FaussillonCécile Jeanpierre
Mar 16, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Skotnicka-KlonowiczM Debiec-Rychter
Aug 1, 1998·Biochimica Et Biophysica Acta·A C SantosL Osorio-Almeida
Oct 29, 1998·Genomics·R W JohnstoneY Shi
Jun 29, 2000·Journal of Pediatric Surgery·J E MasonM A Skinner
Sep 29, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Abel Jacobus BronkhorstPiet J Pretorius
Jun 22, 2000·The Journal of Pathology·S SchulzH Höfler
Jan 26, 2000·British Journal of Cancer·R M PowleslandK W Brown
Jan 9, 2021·Cell Death & Disease·Anees Rahman CherattaSehamuddin Galadari

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