Characterization of Rod Function Phenotypes Across a Range of Age-Related Macular Degeneration Severities and Subretinal Drusenoid Deposits

Investigative Ophthalmology & Visual Science
Oliver J FlynnBrett G Jeffrey

Abstract

To examine spatial changes in rod-mediated function in relationship to local structural changes across the central retina in eyes with a spectrum of age-related macular degeneration (AMD) disease severity. Participants were categorized into five AMD severity groups based on fundus features. Scotopic thresholds were measured at 14 loci spanning ±18° along the vertical meridian from one eye of each of 42 participants (mean = 71.7 ± 9.9 years). Following a 30% bleach, dark adaptation was measured at eight loci (±12°). Rod intercept time (RIT) was defined from the time to detect a -3.1 log cd/m2 stimulus. RITslope was defined from the linear fit of RIT with decreasing retinal eccentricity. The presence of subretinal drusenoid deposits (SDD), ellipsoid (EZ) band disruption, and drusen at the test loci was evaluated using optical coherence tomography. Scotopic thresholds indicated greater rod function loss in the macula, which correlated with increasing AMD group severity. RITslope, which captures the spatial change in the rate of dark adaptation, increased with AMD severity (P < 0.0001). Three rod function phenotypes emerged: RF1, normal rod function; RF2, normal scotopic thresholds but slowed dark adaptation; and RF3, elevated scot...Continue Reading

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Citations

Aug 15, 2018·Investigative Ophthalmology & Visual Science·Rose TanChi D Luu
Feb 13, 2019·Journal of Vision·Oliver J Flynn, Brett G Jeffrey
Aug 12, 2020·Investigative Ophthalmology & Visual Science·Marlene SassmannshausenSteffen Schmitz-Valckenberg
Apr 24, 2021·The British Journal of Ophthalmology·Shrinivas PundlikDeeba Husain
May 18, 2021·American Journal of Ophthalmology Case Reports·Archana NigalyeDeeba Husain
Aug 6, 2021·American Journal of Ophthalmology·Kristin RamingKristina Hess

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NCT02617966

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