Characterization of Russian rabies virus vaccine strain RV-97

Virus Research
A E MetlinA Huovilainen

Abstract

The RV-97 rabies virus vaccine strain is widely used in Russia as a component of the live attenuated oral anti-rabies vaccine "Sinrab". This vaccine has also been used in some other countries, such as Kazakhstan, Belarus, and Ukraine. Entire genome sequencing is an effective tool for studying the genetic properties of virus strains. In this study, a simple technique for obtaining the entire genome sequence of the rabies virus was used. The entire genome sequence and the deduced amino acid sequences of the major viral proteins were compared with those of other rabies vaccine virus strains. The RV-97 strain forms a separate phylogenetic branch and seems to be phylogenetically more related to the group of Japanese vaccine strains. It also contains several unique amino acid changes in known immunodominant sites of G and P proteins.

References

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Citations

Apr 12, 2013·Virologica Sinica·Xiaoyan TaoGuodong Liang
Nov 19, 2011·Virology Journal·Wenqiang JiaoJixing Liu
Feb 8, 2011·Archives of Virology·Takashi MatsumotoAkira Nishizono
Nov 2, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wei LiuYouhua Xie
Aug 19, 2015·PLoS Neglected Tropical Diseases·Thomas F MüllerConrad M Freuling
Sep 27, 2018·International Journal of Veterinary Science and Medicine·A El-Sayed
Dec 15, 2018·Voprosy virusologii·M A LosichT I Aliper

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