Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

European Journal of Medical Research
SeyedAhmad SeyedAlinaghi Shayesteh Jahanfar

Abstract

Coronavirus Disease-2019 (SARS-CoV-2) started its devastating trajectory into a global pandemic in Wuhan, China, in December 2019. Ever since, several variants of SARS-CoV-2 have been identified. In the present review, we aimed to characterize the different variants of SARS-CoV-2 and explore the related morbidity and mortality. A systematic review including the current evidence related to different variants of SARS-CoV-2 and the related morbidity and mortality was conducted through a systematic search utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct; we retrieved all related papers and reports published in English from December 2019 to September 2020. A review of identified articles has shown three main genomic variants, including type A, type B, and type C. we also identified three clades including S, V, and G. Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to life-threatening mutations.The spike D614G amino acid change has become the most common variant since December 2019. From missense mutations found from Gujarat SARS-CoV-2 genomes, C28854T, deleterious mutation...Continue Reading

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Citations

Jul 5, 2021·European Journal of Medical Research·Omid DadrasEsmaeil Mehraeen
Jul 30, 2021·Immunity, Inflammation and Disease·SeyedAhmad SeyedAlinaghiOmid Dadras
Sep 28, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Van-Thuan HoangPhilippe Gautret
Nov 15, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Henry DaniellRonald G Collman

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