PMID: 9184934Apr 1, 1997Paper

Characterization of secretory IgA responses in mice infected with Cryptosporidium parvum

International Journal for Parasitology
R TarazonaD A Blewett

Abstract

Mice inoculated at 5, 21 and 28 days of age with 10(6) or 10(7) Cryptosporidium parvum oocysts became infected but did not exhibit any clinical signs of disease. Specific IgA antibodies were detected in faecal extracts from all infected mice by an indirect immunofluorescent assay. These antibodies first appeared between 11 and 37 days post-infection (dpi) and persisted until the end of the experiment at 55 dpl. They appeared earlier in older mice than in newborn mice. Reduction and resolution of oocyst shedding was not directly related, however, to IgA antibody levels in infected mice. Reactive C. parvum antigens were identified by immunoblotting techniques using faecal and serum samples from infected mice. IgA copro-antibodies reacted specifically with two antigens of 26 and 33 kDa, which were also identified by IgG antibodies in mouse serum. The role of these antibodies in the resolution of infections and the subsequent protection against challenge is unknown.

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Citations

Oct 25, 2000·Veterinary Immunology and Immunopathology·C R WyattL E Perryman
Aug 23, 2002·Microbes and Infection·Michael W Riggs
Nov 15, 2001·Animal Health Research Reviews·C R Wyatt
Aug 19, 2000·Infection and Immunity·S M DannC L Chappell
Aug 30, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hebat-Allah S YousofAyman A El-Badry

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