Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.

The Journal of Pharmacology and Experimental Therapeutics
Dorota ZolkowskaMichael A Rogawski

Abstract

Tetramethylenedisulfotetramine (tetramine; TETS) is a potent convulsant poison that is considered to be a chemical threat agent. To provide a basis for the investigation of antidotes for TETS-induced seizures, we characterized the convulsant activity of TETS in mice and rats when administered by the intraperitoneal, intravenous, oral, and intraventricular routes as a single acute dose and with repeated sublethal doses. In mice, parenteral and oral TETS caused immobility, myoclonic body jerks, clonic seizures of the forelimbs and/or hindlimbs, tonic seizures, and death. The CD₅₀ values for clonic and tonic seizures after oral administration were 0.11 and 0.22 mg/kg, respectively. Intraventricular administration of TETS (5-100 μg) in rats also caused clonic-tonic seizures and death. In mice, repeated sublethal doses of TETS at intervals of 2, 24, and 48 h failed to result in the development of persistent enhanced seizure responsivity ("kindling") as was observed with repeated pentylenetetrazol treatment. In mice, sublethal doses of TETS that produced clonic seizures did not cause observable structural brain damage as assessed with routine histology and Fluoro-Jade B staining 7 days after treatment. However, 1 to 3 days after a si...Continue Reading

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Citations

Aug 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zhengyu CaoIsaac N Pessah
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chunqing ZhaoJohn E Casida
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Oct 2, 2012·Toxicology and Applied Pharmacology·Michael P ShakarjianLibor Velíšek
Jun 22, 2016·Annals of the New York Academy of Sciences·Laxmikant S DeshpandeRobert J DeLorenzo
Jul 8, 2016·Annals of the New York Academy of Sciences·Michael P ShakarjianLibor Velíšek
Sep 13, 2016·Nutritional Neuroscience·Youssef BahbitiAbdelhalem Mesfioui
Jul 29, 2016·Annals of the New York Academy of Sciences·Isaac N PessahPamela J Lein
Feb 8, 2018·Developmental Neurobiology·Marcela LaukováMichael P Shakarjian
Oct 19, 2017·Archives of Toxicology·Brandon PresslyHeike Wulff
Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shane AntrobusIsaac N Pessah

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