Characterization of Selenoprotein M and Its Response to Selenium Deficiency in Chicken Brain

Biological Trace Element Research
Jia-Qiang HuangXin Gen Lei

Abstract

Selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds and can be implicated in calcium responses. SelM may have a functional role in catalyzing free radicals and has been associated with Alzheimer's disease (AD). However, studies of SelM in chicken remain very limited. In this study, two groups of day-old broiler chicks (n = 40/group) were fed a corn-soy basal diet (BD, 13 μg Se/kg) and BD supplemented with Se (as sodium selenite) at 0.3 mg/kg. The brain was collected at 14, 21, 28, and 42 days of age. We performed a sequence analysis and predicted the structure and function of SelM. We also investigated the effects of Se deficiency on the expression of Selt, Selw, and Selm and the Se status in the chicken brain. The results show that Se deficiency induced the lower (P < 0.05) Se content, glutathione peroxidase (GPx), and catalase (CAT) activities; increased (P < 0.05) malondialdehyde (MDA) content; and reduced (P < 0.05) the expression of Selm messenger RNA (mRNA) and protein abundance of SelM in the brain. However, there were no significant brain Selt and Selw mRNA levels by dietary Se deficiency in chicks. The different regulations of these three redox (Rd...Continue Reading

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Citations

May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Oct 30, 2018·Poultry Science·Peter F Surai, Ivan I Kochish
Nov 22, 2019·Biological Trace Element Research·Yilei ZhangShiwen Xu
Aug 8, 2021·International Journal of Molecular Sciences·Elena G VarlamovaSergey V Gudkov

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