PMID: 591199Jan 1, 1977

Characterization of self-stimulation elicited from rat dorsolateral pariaqueductal gray

The International Journal of Neuroscience
R F AckermannS J Ellman


Rats were stereotaxically implanted with chronic bipolar electrodes aimed at the periaqueductal central gray (PCG) and were subsequently tested for intracranial self-stimulation (ICSS) behavior. Consistent and reliable ICSS behavior was elicited from both the midventral and dorsolateral portions of the PCG, the latter result occurring in loci previously reported as predominantly aversive. Midventral PCG ICSS rates were significantly higher than dorsolateral PCG ICSS rates. The higher rates were not accounted for by either current intensity used or motor artifacts. Moreover, both sites displayed reliable ICSS behavior characterized by regular low-variability rates and no seizure activity, seen with other brainstem ICSS sites, but unlike diencephalic and telencephalic ICSS behavior which is characterized by irregular bursts of responding which are highly variable and sometimes accompanied by seizures. The differential ICSS responsivity between PCG structures suggests that they may be mediated by different anatomically-localizable substrates.


Aug 29, 1975·Brain Research·H Akil, J C Liebeskind
Feb 1, 1975·Journal of Comparative and Physiological Psychology·S J EllmanS S Steiner
Jan 1, 1976·The International Journal of Neuroscience·S S SteinerS J Ellman
May 1, 1975·Journal of Comparative and Physiological Psychology·R J Waldbillig
Jan 1, 1969·Journal of Comparative and Physiological Psychology·D L Margules
Sep 1, 1971·Physiology & Behavior·Y H Huang, A Routtenberg
Oct 1, 1973·Physiology & Behavior·S S SteinerS J Ellman
Sep 1, 1973·Behavioral Biology·J M LiebmanJ C Liebeskind
Apr 1, 1974·The Journal of Comparative Neurology·O LindvallU Stenevi
Jan 1, 1969·Journal of Neurosurgery·B S NasholdD G Slaughter
Dec 24, 1971·Science·D J MayerJ C Liebeskind
Jun 1, 1966·The Journal of Comparative Neurology·G Wolf, J Sutin
Apr 7, 1967·Science·R M Cooper, L H Taylor
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA
Sep 1, 1958·Brain : a Journal of Neurology·W J NAUTA
Dec 1, 1958·Journal of Comparative and Physiological Psychology·G H BOWER, N E MILLER
Nov 1, 1962·The American Journal of Physiology·M E OLDS, J OLDS
May 4, 1963·Nature·M J SELLER, R G SPECTOR
Jun 1, 1964·Journal of Comparative and Physiological Psychology·L D REIDP B PORTER

Related Concepts

Cerebral Aqueduct
Potentials, Event-Related
Structure of Locus Ceruleus
Self Stimulation
Cerebral Peduncle

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.