Characterization of septin expression in normal and fibrotic kidneys

Cytoskeleton
Katharina NeubauerBarbara Zieger

Abstract

Chronic kidney disease (CKD) is characterized by the loss of nephrons and worsening organ-fibrosis that leads to deterioration and ultimately the total breakdown of kidney function. Renal fibrosis has become a major public health problem worldwide and necessitates hemodialysis and kidney transplantation in affected patients. CKD is mainly characterized by the activation and proliferation of interstitial fibroblasts and by excessive synthesis and accumulation of extracellular matrix components, causing the disruption of the normal tissue architecture of the kidney. Septins are GTPase proteins associated with membranes, actin filaments, and microtubules and are undoubtedly crucial for cytoskeleton organization. Although some septins are involved in liver fibrosis, they have not been investigated in the context of renal fibrosis. Here, we show that numerous septins are expressed in the healthy kidney and demonstrate in fibrotic mouse kidneys that various septins are remarkably up-regulated in the tubulointerstitium compared to contralateral control kidneys. We observed the same findings in human fibrotic kidneys. In both healthy and fibrotic kidneys, septins are coexpressed with extracellular matrix components, reinforcing the str...Continue Reading

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Citations

Apr 2, 2019·Cytoskeleton·Serge Mostowy, Helge Ewers
Nov 18, 2020·Thrombosis and Haemostasis·Katharina NeubauerBarbara Zieger
Oct 12, 2020·The American Journal of Pathology·Andrei I IvanovFlorian Rieder
Mar 5, 2021·Scientific Reports·Yung-Che ChenUNKNOWN Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE) group

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