Characterization of serotonin and N-acetylserotonin systems in the human epidermis and skin cells.

Journal of Pineal Research
Andrzej T SlominskiDesmond J Tobin


Tryptophan hydroxylase (TPH) activity was detected in cultured epidermal melanocytes and dermal fibroblasts with respective Km of 5.08 and 2.83 mM and Vmax of 80.5 and 108.0 µmol/min. Low but detectable TPH activity was also seen in cultured epidermal keratinocytes. Serotonin and/or its metabolite and precursor to melatonin, N-acetylserotonin (NAS), were identified by LC/MS in human epidermis and serum. Endogenous epidermal levels were 113.18 ± 13.34 and 43.41 ± 12.45 ng/mg protein for serotonin (n = 8/8) and NAS (n = 10/13), respectively. Their production was independent of race, gender, and age. NAS was also detected in human serum (n = 13/13) at a concentration 2.44 ± 0.45 ng/mL, while corresponding serotonin levels were 295.33 ± 17.17 ng/mL (n = 13/13). While there were no differences in serum serotonin levels, serum NAS levels were slightly higher in females. Immunocytochemistry studies showed localization of serotonin to epidermal and follicular keratinocytes, eccrine glands, mast cells, and dermal fibrocytes. Endogenous production of serotonin in cultured melanocytes, keratinocytes, and dermal fibroblasts was modulated by UVB. In conclusion, serotonin and NAS are produced endogenously in the epidermal, dermal, and adnexa...Continue Reading


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Jul 5, 1994·Biochemical Pharmacology·M NaoiH Parvez
Feb 1, 1994·Experimental Dermatology·Andrzej T SlominskiRalf Paus
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Dec 24, 1997·Journal of Pineal Research·Z Trávnícková, H Illnerová
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May 29, 2000·Neuroscience Letters·G Tosini, J C Dirden
Dec 5, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·I P KemaF A Muskiet
Feb 1, 2002·FEBS Letters·Andrzej T SlominskiJacobo Wortsman
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej T SlominskiOlle Johansson
Oct 31, 2002·The Journal of Investigative Dermatology·Andrzej T SlominskiJacobo Wortsman
Jan 4, 2003·Science·Diego J WaltherMichael Bader
May 27, 2003·Journal of Cellular Physiology·Andrzej T SlominskiJacobo Wortsman
Aug 6, 2003·European Journal of Biochemistry·Andrzej T SlominskiJacobo Wortsman
Nov 25, 1961·Biochimica Et Biophysica Acta·H WEISSBACHJ AXELROD
Oct 16, 2003·Biochimica Et Biophysica Acta·Andrzej T SlominskiJacobo Wortsman
Dec 18, 2003·Archives of Biochemistry and Biophysics·Igor SemakAndrzej T Slominski
Sep 24, 2004·Physiological Reviews·Andrzej T SlominskiJacobo Wortsman
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej T SlominskiDesmond J Tobin
Aug 17, 2006·The Journal of Investigative Dermatology·Sergei A GrandoKarin U Schallreuter
Jul 12, 2007·Seminars in Immunopathology·Peter M Elias
Dec 15, 2007·Journal of Pineal Research·Tobias W FischerRalf Paus
Dec 25, 2007·Trends in Endocrinology and Metabolism : TEM·Andrzej T SlominskiRalf Paus
Jan 8, 2008·Experimental Dermatology·Klas NordlindAndrzej T Slominski
Aug 5, 2008·Trends in Pharmacological Sciences·Mark J MillanClotilde Mannoury la Cour
May 5, 2009·Molecular and Cellular Endocrinology·Michal A ŻmijewskiAndrzej T Slominski
Mar 9, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Peter M EliasJohn Jack W Williams
Jun 16, 2011·American Journal of Physiology. Endocrinology and Metabolism·Cezary SkobowiatAndrzej T Slominski
Mar 21, 2012·Journal of Mass Spectrometry : JMS·Melissa D CarterDavid L Hachey
Aug 17, 2012·Advances in Anatomy, Embryology, and Cell Biology·Andrzej T SlominskiJeffery D Steketee
Feb 1, 2013·The British Journal of Dermatology·Cezary SkobowiatAndrzej T Slominski
Apr 27, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tae-Kang KimAndrzej T Slominski
Aug 14, 2013·Endocrine Reviews·Andrzej T SlominskiJean Rivier
May 29, 2014·Journal of Pineal Research·Zorica JanjetovicAdrzej T Slominski
Oct 2, 2014·International Journal of Molecular Sciences·Andrzej T SlominskiTobias W Fischer
May 20, 2015·Steroids·Andrzej T SlominskiRobert C Tuckey
Apr 15, 2016·International Journal of Molecular Sciences·Eun Ju OhJae Sung Hwang
Mar 23, 2017·Endocrinology·Alyce M MartinDamien J Keating
May 4, 2017·Journal of Biological Rhythms·Peter S BacklundDavid C Klein
May 11, 2017·Nature Reviews. Gastroenterology & Hepatology·Stephanie N Spohn, Gary M Mawe
Sep 3, 2017·Cellular and Molecular Life Sciences : CMLS·Russel J ReiterBing Xu
Oct 17, 2017·Biochemistry·Kasper D TidemandHans E M Christensen
Oct 22, 2017·British Journal of Pharmacology·Stephen Ph AlexanderCGTP Collaborators
Feb 13, 2018·The Journal of Investigative Dermatology·Andrzej T SlominskiRalf Paus
Mar 17, 2018·Endocrinology·Andrzej T SlominskiRalf Paus
Mar 30, 2018·International Journal of Molecular Sciences·Alia SadiqSaeid Amini-Nik
Sep 15, 2018·Endocrine Reviews·José Cipolla-Neto, Fernanda Gaspar do Amaral
Nov 30, 2018·International Journal of Molecular Sciences·Konrad KleszczyńskiAndrzej T Slominski


Apr 25, 2020·International Journal of Molecular Sciences·Iona J MacDonaldChih-Hsin Tang
Sep 10, 2020·Frontiers in Bioengineering and Biotechnology·Micaela BalcázarAndrés Caicedo
Mar 3, 2021·Journal of Pineal Research·Bernadetta BilskaKonrad Kleszczyński
Mar 16, 2021·Molecular and Cellular Endocrinology·Slominski RmTuckey Rc

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