Characterization of seven cocaine- and amphetamine-regulated transcripts (CARTs) differentially expressed in the brain and peripheral tissues of Solea senegalensis (Kaup)

General and Comparative Endocrinology
Kruno BonacicSofia Morais

Abstract

CART (cocaine- and amphetamine-regulated transcript) is a peptide with neurotransmitter and neuroendocrine functions with several key roles, both centrally and peripherally. In mammals there is a single gene that produces two alternatively spliced variants in rat and a single transcript in human but in teleosts multiple genes have been found. In the present study we report the existence of seven transcripts in Senegalese sole and characterize their sequences and phylogenetic relationships, as well as their expression patterns in the brain and peripheral tissues, and in response to feeding. Both cart2a and cart4 showed a ubiquitous expression in the brain, while cart1a, cart1b and cart3a were similarly expressed and had higher transcript levels in the mesencephalon, followed by the diencephalon. On the other hand, cart2b showed a main expression in the olfactory bulbs, and cart3b was predominantly expressed in the spinal cord. The expression profile in peripheral tissues differed substantially between cart's, even between more recently duplicated genes. Collectively, all the tissues examined, except the muscle, express at least one of the different cart's, although the highest transcript levels were found in the brain, gonads (o...Continue Reading

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Citations

Jul 30, 2016·General and Comparative Endocrinology·Hélène VolkoffJosé Eurico Possebon Cyrino
Oct 28, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hélène VolkoffJosé Eurico Possebon Cyrino
Oct 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marta Conde-SieiraJosé L Soengas
May 2, 2017·Frontiers in Endocrinology·Ivar RønnestadHélène Volkoff
Mar 8, 2019·Scientific Reports·Elisavet KaitetzidouElena Sarropoulou

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