Characterization of single semiflexible filaments under geometric constraints.

The European Physical Journal. E, Soft Matter
Sarah KösterT Pfohl

Abstract

Confinement effects on single semiflexible macromolecules are of central importance for a fundamental understanding of cellular processes involving biomacromolecules. To analyze the influence of confinement on the fluctuations of semiflexible macromolecules we study individual actin filaments in straight and curved microchannels. We experimentally characterize the segment distributions for fluctuating semiflexible filaments in microchannels as a function of the channel width. Moreover, the effect of channel curvature on the filament fluctuations is investigated. We find quantitative agreement between experimental results, Monte Carlo simulations, and the analytical description. This allows for determination of the persistence length of actin filaments, the deflection length, which characterizes the confinement effects, and the scaling exponents for the segment distribution of semiflexible macromolecules.

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Citations

Jul 26, 2013·The Journal of Chemical Physics·Tobias A KampmannJan Kierfeld
Jan 13, 2009·Cell Motility and the Cytoskeleton·Sarah Köster, Thomas Pfohl
Jan 27, 2015·IEEE Transactions on Nanobioscience·J HajneD V Nicolau
Jun 18, 2009·Lab on a Chip·Heather M EvansThomas Pfohl
Apr 22, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Raghunath ChelakkotGerhard Gompper
Feb 23, 2019·The European Physical Journal. E, Soft Matter·Somiéalo Azote, Kristian K Müller-Nedebock
Dec 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·E WernerB Mehlig
Jul 10, 2017·The Journal of Chemical Physics·Tobias A Kampmann, Jan Kierfeld
Apr 2, 2019·Physical Review Letters·Lila BouzarIgor M Kulić
Sep 24, 2015·Soft Matter·Feng-Ching Tsai, Gijsje Hendrika Koenderink
Sep 11, 2019·Physical Review. E·Pavel Castro-Villarreal, J E Ramírez
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Katja OstermeirErwin Frey
Apr 3, 2012·Physical Review Letters·Bernd Nöding, Sarah Köster
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Theodore W BurkhardtGerhard Gompper
Mar 17, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Florian ThüroffErwin Frey

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