Characterization of social behaviors in caspase-3 deficient mice

Scientific Reports
Shih-Ching LoMorgan Sheng

Abstract

Impaired social interaction is a defining feature of autism spectrum disorder, a neurodevelopmental disorder that shows a strong male preponderance in prevalence. Studies have identified neural circuits, neuromodulators and genetic factors involved in social behaviors, but mechanistic understanding of gender-specific social deficits is lacking. We report that deletion of the caspase-3 gene, encoding a protease with functions in apoptosis and neural plasticity, alters specific social behaviors in male mice, while leaving females unaffected. Casp3(-/-) mice showed normal behavioral responses to olfactory cues from food, neutral chemical and biological sources. Both Casp3(-/-) males and females displayed robust social exploration, sociability, recognition and preference for an enclosed novel mouse in the three-chamber test. However, Casp3(-/-) males showed significantly reduced social interaction behaviors when exposed to a freely moving novel mouse, including decreased interaction time and diminished mounting. Thus caspase-3 is essential for a subset of social behaviors, but despite similar hyper-locomotion in both sexes, only male Casp3(-/-) mice exhibited social interaction deficits, which is interesting given the male bias of ...Continue Reading

References

Aug 1, 1971·Psychological Reports·M L Cheal, R L Sprott
Jul 11, 2000·Nature Genetics·J N FergusonJ T Winslow
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elena CholerisSonoko Ogawa
Dec 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isadora F BielskyLarry J Young
Sep 4, 2004·Genes, Brain, and Behavior·J J NadlerJ N Crawley
Aug 31, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Marina C PeluffoMarta Tesone
Oct 3, 2007·Genes, Brain, and Behavior·K Scearce-LevieL Mucke
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
Jul 9, 2010·Trends in Genetics : TIG·Roberto ToroThomas Bourgeron
May 19, 2012·Nature Reviews. Neuroscience·Bradley T Hyman, Junying Yuan
Jun 16, 2012·Nature·Michael J SchmeisserTobias M Boeckers
Jul 17, 2012·Trends in Neurosciences·Marcello D'AmelioFrancesco Cecconi
Oct 15, 2013·Expert Review of Neurotherapeutics·Kevin M AntshelStephen V Faraone
Jan 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ali ErtürkMorgan Sheng
Jan 7, 2015·Neurobiology of Stress·Annaliese K Beery, Daniela Kaufer
Feb 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shih-Ching LoMorgan Sheng

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Citations

Jul 21, 2016·Behavioural Brain Research·Sarah K LawsonNancy S Woehrle
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chun-Hsien ChuH Sunny Sun
May 30, 2020·Journal of Neuroscience Research·Alessandro Piccin, Angelo Contarino
Sep 13, 2017·Frontiers in Molecular Neuroscience·Yonglu TianChen Zhang
Jan 10, 2018·Bioengineering & Translational Medicine·Anusha Garapaty, Julie A Champion
Aug 15, 2017·Frontiers in Behavioral Neuroscience·Katsiaryna V GrisDenis Gris
Oct 7, 2020·PLoS Computational Biology·Ugne Klibaite, Joshua W Shaevitz
Dec 18, 2020·Frontiers in Veterinary Science·Haley E RymutSandra L Rodriguez-Zas
May 25, 2021·Frontiers in Pharmacology·Frank Adu-NtiXin-Ming Ma
Jul 24, 2021·Neurobiology of Disease·Sergei V BaranovRobert M Friedlander

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