Characterization of sodiated glycerol phosphatidylcholine phospholipids by mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Pedro DominguesAntónio J V Ferrer-Correia

Abstract

Fast atom bombardment mass spectrometry in the positive mode was used for the characterization of sodiated glycerol phosphatidylcholines. The relative abundance (RA) of the protonated species is similar to the RA of the sodiated molecular species. The sodiated fragment ion, [M + Na - 59](+), corresponding to the loss of trimethylamine, and other sodiated fragment ions, were also observed. The decomposition of the sodiated molecule is very similar for all the studied glycerol phosphatidylcholines, in which the most abundant ion corresponds to a neutral loss of 59 Da. Upon collision-induced dissociation (CID) of the [M + Na](+) ion informative ions are formed by the losses of the fatty acids in the sn-1 and sn-2 positions. Other major fragment ions of the sodiated molecule result from loss of non-sodiated and sodiated choline phosphate, [M + Na - 183](+), [M + Na - 184](+.) and [M + Na - 205](+), respectively. The main CID fragmentation pathway of the [M + Na - 59](+) ion yields the [M + Na - 183](+) ion, also observed in the CID spectra of the [M + Na](+) molecular ion. Other major fragment ions are [M + Na - 205](+) and the fragment ion at m/z 147. Collisional activation of [M + Na - 205](+) results in charge site remote fragme...Continue Reading

Citations

Oct 29, 2005·Journal of the American Society for Mass Spectrometry·Shelley N JacksonAmina S Woods
Apr 30, 2010·Journal of the American Society for Mass Spectrometry·Marion GirodR Graham Cooks
Sep 28, 2010·Journal of the American Society for Mass Spectrometry·Berwyck L J PoadStephen J Blanksby
Apr 11, 2003·Journal of the American Society for Mass Spectrometry·Fong-Fu Hsu, John Turk
Apr 11, 2003·Journal of the American Society for Mass Spectrometry·Khalid A Al-SaadN Richard Knowles
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Justin M WisemanR Graham Cooks
Jan 27, 2011·Journal of Lipid Research·Hay-Yan J WangHsuan-Wen Wu
Jan 28, 2016·Analytical Chemistry·Tânia MeloMaria Rosario M Domingues
Aug 2, 2008·Chemistry and Physics of Lipids·M Rosário M DominguesPedro Domingues
Dec 9, 2015·International Journal of Mass Spectrometry·Robert E DeimlerGlen P Jackson
Nov 29, 2011·The Analyst·Shane R EllisStephen J Blanksby
Nov 5, 2013·Analytical Chemistry·Whitney L StuttsRichard A Yost
Jan 4, 2003·Rapid Communications in Mass Spectrometry : RCM·Yen-Peng HoKuang-Hao Deng
Oct 13, 2001·Journal of Mass Spectrometry : JMS
Aug 31, 2002·Rapid Communications in Mass Spectrometry : RCM·Yen-Peng Ho, Ping-Chen Huang
May 10, 2017·Journal of the American Society for Mass Spectrometry·Shane R EllisStephen J Blanksby
Aug 13, 2021·Journal of the American Society for Mass Spectrometry·Shunji KatoKiyotaka Nakagawa
Sep 3, 2021·Journal of the American Chemical Society·Carla KirschbaumKevin Pagel

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