PMID: 43583Dec 1, 1979

Characterization of somatostatin release from the pancreas: the role of potassium

Scandinavian Journal of Clinical and Laboratory Investigation
K HermansenH Orskov


The effect of potassium on somatostatin secretion from the isolated perfused canine pancreas was studied. Potassium stimulated dose-dependent somatostatin release in a monophasic response pattern. The effect of potassium was abolished in the absence of calcium. Perfusion of 1 micronmol/l atropine and 1 micronmol/l propranolol was without effect on the potassium induced somatostatin release. The results suggest that the stimulatory effect of potassium on somatostatin release is secondary to increases in calcium influx into the D cell. The sympathetic and parasympathetic nerve endings in the pancreas are apparently not involved in the potassium mediated secretory processes.


Jun 26, 2008·American Journal of Physiology. Endocrinology and Metabolism·Leon S FarhyAnthony L McCall
Apr 1, 1981·The Journal of Surgical Research·K R SirinekS Cataland
Mar 1, 1981·The American Journal of Medicine·J E Gerich
May 19, 2018·Nature Reviews. Endocrinology·Patrik Rorsman, Mark O Huising
Jan 5, 2010·Journal of Diabetes Science and Technology·Leon S Farhy, Anthony L McCall


Jan 14, 1978·Diabetologia·R LuftT Hökfelt
Nov 1, 1977·FEBS Letters·A C BoscheroW J Malaisse
Jan 1, 1978·Advances in Metabolic Disorders·S C Woods, D Porte
Apr 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·K Hermansen, J Iversen
Nov 1, 1976·Metabolism: Clinical and Experimental·G S PattonR H Unger
Aug 1, 1977·Diabetologia·J Iversen, K Hermansen
Dec 8, 1973·Lancet·K G AlbertiH Orskov
Apr 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J Iversen
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews
Feb 1, 1968·The Journal of Physiology·C N Hales, R D Milner
Jul 1, 1969·Biochemical Pharmacology·R M Marchbanks
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltR Luft

Related Concepts

Glucose, (beta-D)-Isomer
Dose-Response Relationship, Drug
Autonomic Nervous System

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.