PMID: 43583Dec 1, 1979

Characterization of somatostatin release from the pancreas: the role of potassium

Scandinavian Journal of Clinical and Laboratory Investigation
K HermansenH Orskov

Abstract

The effect of potassium on somatostatin secretion from the isolated perfused canine pancreas was studied. Potassium stimulated dose-dependent somatostatin release in a monophasic response pattern. The effect of potassium was abolished in the absence of calcium. Perfusion of 1 micronmol/l atropine and 1 micronmol/l propranolol was without effect on the potassium induced somatostatin release. The results suggest that the stimulatory effect of potassium on somatostatin release is secondary to increases in calcium influx into the D cell. The sympathetic and parasympathetic nerve endings in the pancreas are apparently not involved in the potassium mediated secretory processes.

References

Jun 26, 2008·American Journal of Physiology. Endocrinology and Metabolism·Leon S FarhyAnthony L McCall
Apr 1, 1981·The Journal of Surgical Research·K R SirinekS Cataland
Mar 1, 1981·The American Journal of Medicine·J E Gerich
May 19, 2018·Nature Reviews. Endocrinology·Patrik Rorsman, Mark O Huising
Jan 5, 2010·Journal of Diabetes Science and Technology·Leon S Farhy, Anthony L McCall

Citations

Jan 14, 1978·Diabetologia·R LuftT Hökfelt
Nov 1, 1977·FEBS Letters·A C BoscheroW J Malaisse
Jan 1, 1978·Advances in Metabolic Disorders·S C Woods, D Porte
Apr 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·K Hermansen, J Iversen
Nov 1, 1976·Metabolism: Clinical and Experimental·G S PattonR H Unger
Aug 1, 1977·Diabetologia·J Iversen, K Hermansen
Dec 8, 1973·Lancet·K G AlbertiH Orskov
Apr 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·J Iversen
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews
Sep 1, 1970·The Journal of Physiology·P M Dean, E K Matthews
Feb 1, 1968·The Journal of Physiology·C N Hales, R D Milner
Jul 1, 1969·Biochemical Pharmacology·R M Marchbanks
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltR Luft

Related Concepts

Calcium
Potassium
Perfusion
Glucose, (beta-D)-Isomer
Atropen
Stilamin
Rexigen
Dose-Response Relationship, Drug
Autonomic Nervous System
SST

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