Characterization of spontaneous mammary gland carcinomas in female baboons

Journal of Medical Primatology
Jennifer A LuthBreton F Barrier

Abstract

Spontaneous mammary gland carcinomas occurred in five baboons during a 13-year period at Southwest Foundation for Biomedical Research. The affected baboons ranged in age from 21 to 33 years. Menopause in the baboon occurs at approximately 26 years of age. All five animals had typical invasive ductal carcinoma. Morphologically, the tumors were characterized by neoplastic cells arranged from pseudopapillary and cribiform to more poorly differentiated solid cellular growth patterns. Additional features included lack of tubule formation (4/5), marked nuclear pleomorphism (5/5), a high mitotic rate (4/5) and tumor necrosis (4/5). Applying a grading system used for breast cancer in women, four tumors were graded as poorly differentiated carcinomas and one was graded as moderately differentiated. Co-existent ductal carcinoma in situ (DCIS) was observed in three of the mammary tumors. Metastases to the regional lymph nodes were confirmed in two animals, both with histological evidence of lymphovascular invasion in the primary tumor. Distant metastases were observed in only one animal. Immunohistochemical staining for human therapeutic markers revealed 2/5 tumors strongly positive for estrogen receptor, 1/5 strongly positive for progest...Continue Reading

References

Dec 1, 1989·Journal of Reproductive Immunology·C S Bambra, M Isahakia
Aug 1, 1971·Teratology·J A Bollert, A G Hendrickx
Jan 1, 1982·Cytogenetics and Cell Genetics·J Marks
Feb 21, 1996·Journal of the National Cancer Institute·S SjögrenJ Bergh
Oct 28, 1997·Fertility and Sterility·T M D'Hooghe
Jul 21, 1998·Molecular Phylogenetics and Evolution·M GoodmanC P Groves
Mar 14, 2000·Oncogene·L Hennighausen
May 8, 2000·Seminars in Reproductive Endocrinology·A T FazleabasR C Jaffe
Feb 13, 2001·Microscopy Research and Technique·R D Cardiff
Mar 16, 2001·Breast Cancer Research : BCR·L Hennighausen
Sep 23, 2003·Mechanisms of Ageing and Development·L J MartinA G Comuzzie
Mar 15, 2006·Gynecologic Oncology·Breton F BarrierEdward R Kost
Jul 19, 2006·Veterinary Pathology·C E WoodJ M Cline

❮ Previous
Next ❯

Citations

Jan 14, 2011·Journal of Medical Primatology·Yugendar R BommineniGene B Hubbard
Jan 8, 2014·Journal of Medical Primatology·Boris A Lapin, Lelita A Yakovleva
Feb 4, 2014·Journal of Medical Primatology·Edward J DickGene B Hubbard
Apr 1, 2017·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Nancy A Carpenter, Erika K Crook
Jan 6, 2021·Laboratory animal research·Fitriya N Dewi, J Mark Cline
Jun 16, 2021·ILAR Journal·Chandra SaravananHsi-Yu Yen
Sep 14, 2021·American Journal of Primatology·Anneke MorescoDalen W Agnew
Sep 30, 2021·Journal of Medical Primatology·J Díaz-DelgadoG Gomez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.