PMID: 6402551Mar 1, 1983Paper

Characterization of structural properties for morphologic differentiation of melanosomes. III. free and protein-bound dopa and 5-S-cysteinyldopa in B16 and Harding-Passey melanomas

The Journal of Investigative Dermatology
S ItoK Jimbow

Abstract

This study analyzed the free and protein-bound forms of dopa, 5-S-cysteinyldopa (5-S-CD), and 5-S-glutathionedopa (5-S-GD) in B16 and Harding-Passey (HP) mouse melanomas to investigate the role of these catechols for melanogenesis and melanosome morphogenesis, inasmuch as these tumors produce melanosomes different in color and ultrastructure, i.e., eumelanosome type in B16 and pheomelanosome type in HP. Between B16 and HP mouse melanomas, however, we found (a) no significant difference in the level of free dopa and 5-S-CD in melanosomes and tumors, although the levels of these catechols reflected well the type of melanogenesis in control hair of normal mice, (b) a significant difference in free 5-S-GD level, which might, in part, reflect the observed difference in melanogenesis, and (c) no apparent difference in the level of bound dopa and 5-S-CD in either melanosomes or tumors. Thus, the striking difference in the color of melanosomes between B16 and HP melanomas seems to be related primarily to the content--not the type--of melanin pigments.

Citations

Nov 1, 1992·The Journal of Dermatology·S Ito
Sep 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·Z L Hegedus, U Nayak
Jul 15, 1985·Experientia·S ItoG Prota
Aug 1, 1987·Photochemistry and Photobiology·W H Koch, M R Chedekel
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Dec 1, 1986·Photochemistry and Photobiology·W H Koch, M R Chedekel
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·J Hartleb, R Arndt

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