Characterization of synergistic embryotoxicity of nickel and buprofezin in zebrafish

Environmental Science & Technology
Tingting KuNan Sang

Abstract

Multiple pollutants, usually at low levels, coexist and may interact in the environment. It is therefore important to analyze the toxicity of mixtures of coexisting chemicals to evaluate the potential ecological risk. Concern regarding the co-occurrence and combined bioeffects of heavy metals and organic insecticides in aquatic settings has existed for many years, but a clear understanding of the interactions between and potential combined toxicity of these chemicals remains elusive. In the present study, the combined effects of the heavy metal nickel (NiSO4) and insect growth regulator buprofezin on the induction of embryo toxicity in zebrafish were assessed. By applying nonlinear regression to the concentration-response data with each of the chemicals using the Hill and Langmuir functions and computing the predictions using the model of concentration addition (CA), we confirmed that NiSO4 and buprofezin acted together to produce synergistic embryotoxicity in zebrafish. Subsequently, we further found that the combination of NiSO4 and buprofezin formed a complex that facilitated the uptake of nickel (Ni) and buprofezin by the embryos. Following this, we clarified that an oxidative mechanism of the complex might underlie the syn...Continue Reading

References

Dec 23, 1998·Environmental Health Perspectives·M M MumtazP R Durkin
Mar 3, 1999·Ecotoxicology and Environmental Safety·L Martínez-TabcheM A Grajeda y Ortega
Jan 12, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·J A Steevens, W H Benson
May 4, 2001·Environmental Health Perspectives·J PayneA Kortenkamp
Oct 24, 2003·Environmental Science & Technology·Eric F PaneChris M Wood
Apr 27, 2004·Bulletin of Environmental Contamination and Toxicology·C DasA Chowdhury
Sep 1, 2004·The Science of the Total Environment·R M Cenci, J-M Martin
Jun 1, 2005·Journal of Pharmaceutical and Biomedical Analysis·Subbiah Deepa, Ashok K Mishra
Jun 6, 2006·Biochimica Et Biophysica Acta·Meng-Xia XieYing-Dian Wang
Jan 5, 2008·Environmental Health Perspectives·Andreas Kortenkamp
Jan 5, 2008·Environmental Health Perspectives·Andreas KortenkampThomas Backhaus
Dec 3, 2008·Fish & Shellfish Immunology·K VijayavelH Thilagam
Feb 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ezra R LoweMichael J Bartels
Sep 15, 2009·Environmental Science & Technology·Cristina IspasKenneth N Wallace
Dec 19, 2009·Environmental Health Perspectives·Marcelo J WolanskyKevin M Crofton
Jan 6, 2010·Environmental Health Perspectives·Sofie ChristiansenUlla Hass
Mar 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiongjie Shi, Bingsheng Zhou
Feb 18, 2012·Journal of Agricultural and Food Chemistry·Chao LiShun-Peng Li
Sep 4, 2012·Bulletin of Environmental Contamination and Toxicology·Yong LiuChengju Wang
Mar 19, 2013·The Science of the Total Environment·Pham Van ToanFabrice G Renaud

❮ Previous
Next ❯

Citations

Jul 16, 2017·Applied and Environmental Microbiology·Xueting ChenXin Yan
Mar 2, 2018·Current Zoology·Matthew K LeFauve, Victoria P Connaughton
Apr 3, 2019·Environmental Science and Pollution Research International·Chan ZhangLiangqi Zhao
Dec 17, 2019·The Science of the Total Environment·Bojan NatarajMathan Ramesh
Jan 9, 2021·The Science of the Total Environment·Pottanthara Ashokan AnilaMathan Ramesh
Nov 6, 2017·The Science of the Total Environment·Débora Dreher NabingerCarla Denise Bonan
May 19, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kaikai LiuDaode Yu
Aug 8, 2021·International Journal of Molecular Sciences·Ferry SaputraChung-Der Hsiao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.