Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies

Disease Markers
Che-Mai ChangWei-Chiao Chang

Abstract

Rheumatoid arthritis (RA) is a systematic autoimmune disease, predominantly causing chronic polyarticular inflammation and joint injury of patients. For the treatment of RA, biologic disease-modifying antirheumatic drugs (bDMARDs) have been used to reduce inflammation and to interfere with disease progression through targeting and mediating the immune system. Although the therapeutic effects of bDMARDs in RA patients have been widely reported, whether these drugs also play important roles in T-cell repertoire status is still unclear. We therefore designed the study to identify the role of T-cell repertoire profiles in RA patients with different types of bDMARD treatments. A high-throughput sequencing approach was applied to profile the T-cell receptor beta chain (TCRB) repertoire of circulating T lymphocytes in eight patients given adalimumab (anti-TNF-α) with/without the following use of either rituximab (anti-CD20) or tocilizumab (anti-IL6R). We subsequently analyzed discrepancies in the clonal diversity and CDR3 length distribution as well as usages of the V and J genes of TCRB repertoire and interrogated the association between repertoire diversity and disease activities followed by the treatment of bDMARDs in these RA pati...Continue Reading

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Citations

May 10, 2020·International Journal of Environmental Research and Public Health·Andrzej PawlikVioletta Dziedziejko
Aug 12, 2020·Clinical and Translational Medicine·Che-Mai ChangYun Yen
May 6, 2020·International Journal of Molecular Sciences·Bong Jun KimJin Pyeong Jeon
Sep 6, 2020·Current Opinion in Biotechnology·Johanna ChiffelleAlexandre Harari

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Software Mentioned

R
MiXCR
Bioconductor
Comprehensive R Archive Network ( CRAN )

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