Characterization of tablet film coatings using a laser-induced breakdown spectroscopic technique

AAPS PharmSciTech
M Cecilia MadambaElizabeth Kwong

Abstract

Laser-induced breakdown spectroscopy (LIBS) was evaluated as an early phase process analytical technology (PAT) tool for the rapid characterization of pharmaceutical tablet coatings. Measurement of coating thickness, uniformity, and photodegradation-predictive potential of the technique were evaluated. Model formulation tablets were coated with varying amounts (2%-4% wt/wt) of red and yellow Opadry II, and a pulsed laser was used to sample at multiple sites across the tablet face. LIBS was able to successfully detect the emissions of Fe and Ti in the coated samples, and a proportional increase in signal with coating thickness was observed. Batch-to-batch variability in the coating procedure was also easily monitored by LIBS. The coating thickness was non-uniform across the tablet surface with higher thickness at the edges, likely due to the concave shape of the tablet. Film coating levels and color of the film had been subjected to photostability studies according to the International Conference on Harmonisation (ICH) guideline to determine effectiveness of the film coats. LIBS measurements of coating thickness provided a good correlation (R (2) > 0.99) to photodegradation as measured by high-performance liquid chromatography (...Continue Reading

References

Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Mark D MoweryRobert A Reed
Jun 4, 2004·Journal of Pharmaceutical Sciences·W Aman, K Thoma
Dec 16, 2005·AAPS PharmSciTech·Jean-Francois ArchambaultElizabeth Kwong

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Citations

Jan 11, 2012·AAPS PharmSciTech·Atul DubeyFernando J Muzzio
Feb 27, 2014·Pharmaceutical Research·Masahiro NiwaKatsuhide Terada
Oct 13, 2012·Drug Development and Industrial Pharmacy·M Akhlaq MughalSteven H Neau
Jul 24, 2015·Journal of Pharmaceutical Sciences·Anjali M Agrawal, Preetanshu Pandey
Dec 4, 2012·International Journal of Pharmaceutics·Wycliffe S OmwanchaSteven H Neau
Jul 23, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniela BrockPeter Kleinebudde
Nov 5, 2016·Journal of Pharmaceutical Sciences·Yue DongYao-Chun Shen
Jun 21, 2021·Advanced Drug Delivery Reviews·Muhammad Sohail ArshadKendal Pitt

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