Characterization of thalamic neuronal responses to urinary bladder distention, including the effect of acute spinal lesions in the rat

The Journal of Pain : Official Journal of the American Pain Society
Meredith T RobbinsT J Ness

Abstract

Chronic visceral pain has proved to be difficult to treat. This study characterized urinary bladder distention (UBD)-evoked responses of neurons located within the ventrobasal group of the thalamus. Units were also characterized for responses to cutaneous stimuli and colorectal distention (CRD). In addition, the effects of spinal lesions on UBD-evoked responses were examined in a subset of neurons. After a stable response to UBD was established, 3 sequential lesions of the spinal cord at the mid-cervical level were performed, and responses to UBD were determined 1 and 5 minutes later. A majority of the neurons in the ventrobasal group of the thalamus were excited by UBD, demonstrated graded responses to graded distention pressures, and responded to cutaneous stimulation. No correlation between the magnitude of the responses of thalamic neurons to UBD and CRD was found. UBD-evoked thalamic neuronal activity was significantly attenuated after dorsal midline lesions of the spinal cord. The present study is a quantitative description of ventrobasal thalamic neuronal responses to UBD in the rat and provides direct neurophysiologic evidence that nociceptive information from the urinary bladder to the ventrobasal group of the thalamus...Continue Reading

References

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Citations

Aug 10, 2007·European Urology·Thomas M KesslerAlain Kaelin-Lang
Feb 26, 2016·The Journal of Urology·Katelyn E Sadler, Benedict J Kolber
Apr 18, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·J-M Soler, G Amarenco
Sep 27, 2019·The Journal of Spinal Cord Medicine·Gregory M HolmesNaomi Kleitman
Oct 7, 2020·International Neurourology Journal·Jin Wook KimKhae Hawn Kim

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