Abstract
In the present study, we characterized the effects of peroxisome proliferators (PP) on adipose tissue in mice. Treatment with potent PP, such as perfluorooctanoic acid (PFOA), 2-methyl-2-(p(1,2,3,4-tetrahydroxy-naphthyl)-phenoxy)propionic acid, (4-chloro-6-(2,3-xylidino)2-pyrimidinylthio) acetic acid, and di(2-ethylhexyl)phthalate, caused dramatic decreases in adipose tissue weight, whereas the moderately potent PP, acetylsalicylic acid, had a relatively weak effect. This decrease in weight reflects a loss of fat from adipocytes rather than a loss of cells, as demonstrated by constant DNA content. The dose-dependency and time-course experiments indicate that peroxisome proliferation occurs simultaneously with or prior to adipose tissue atrophy. Thus, hepatic peroxisome proliferation might result in the increased mobilization of lipids and lipid utilization in liver. The enhanced adipose tissue hormone-sensitive lipase (HSL) activity and down-regulated lipoprotein lipase (LPL) activity observed upon PP treatment might, at least in part, explain the loss of fat via increased FA release from adipocytes and/or decreased FA uptake from the circulation, respectively. In addition, the possible involvement of the increased tumor necros...Continue Reading
References
Jan 1, 1992·Journal of Biochemical Toxicology·A K SohleniusJ W DePierre
Aug 17, 1990·Biochimica Et Biophysica Acta·B LundgrenJ W DePierre
Jun 1, 1989·Atherosclerosis·C L MalmendierL De Roy
Jun 27, 1986·Biochimica Et Biophysica Acta·R BrandesJ Bar-Tana
May 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Lundgren, J W DePierre
Nov 4, 1988·Biochimica Et Biophysica Acta·E HerreraG Quack
Feb 1, 1988·Endocrine Reviews·B Beutler, A Cerami
Dec 10, 1986·Biochimica Et Biophysica Acta·M S Poosch, R K Yamazaki
Dec 1, 1972·Analytical Biochemistry·L L BieberT Helmrath
Aug 15, 1970·Nature·U K Laemmli
Sep 1, 1971·The American Journal of Physiology·M Di GirolamoJ W Fertig
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P StrålforsP Belfrage
Jan 1, 1994·The Japanese Journal of Physiology·S K SahaA Kuroshima
Jan 1, 1993·Science·G S HotamisligilB M Spiegelman
Feb 1, 1995·The Journal of Clinical Investigation·B StaelsJ Auwerx
Jun 15, 1994·Biochemical Pharmacology·Y CaiJ W DePierre
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·G KreyW Wahli
Jan 1, 1993·Biology of the Cell·C DreyerW Wahli
Sep 27, 1993·Journal of Immunological Methods·L ShapiraW A Soskolne
Feb 2, 1996·Science·G S HotamisligilB M Spiegelman
Jul 26, 1996·Biochimica Et Biophysica Acta·K SchoonjansJ Auwerx
Jul 1, 1996·Atherosclerosis·J AuwerxB Staels
Dec 13, 1996·The Journal of Biological Chemistry·B ZhangD E Moller
Apr 21, 1998·Toxicologic Pathology·J M WardF J Gonzalez
Jun 20, 1998·Chemical Research in Toxicology·M Adinehzadeh, N V Reo
Jun 10, 1998·Regulatory Toxicology and Pharmacology : RTP·R C CattleyW Wahli
Nov 25, 1998·Journal of the National Cancer Institute·F J GonzalezR C Cattley
Jun 22, 1999·Infection and Immunity·M R HillJ M Gimble
Jun 26, 1999·Diabetologia·T TanakaK Nakao
Jul 21, 1999·Cellular and Molecular Life Sciences : CMLS·L GelmanJ Auwerx
Feb 11, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F Hube, H Hauner
Feb 26, 2000·Journal of Medicinal Chemistry·T M WillsonB R Henke
May 29, 2000·The Journal of Biological Chemistry·M Guerre-MilloB Staels
Sep 2, 2000·Diabetes·N Tsuboyama-KasaokaO Ezaki
Nov 25, 2000·Clinical and Experimental Immunology·Q YangJ W Depierre
Feb 28, 2001·FEBS Letters·F P ManciniF Goglia
Oct 13, 2001·Biochemical Pharmacology·Q YangJ W DePierre
May 30, 2002·Biochemical Pharmacology·Qian YangJoseph W DePierre
Dec 8, 1962·Nature·P B GARLAND, P J RANDLE
Citations
Jun 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nina SkottováJitka Ulrichová
Sep 2, 2003·Biochemical Pharmacology·Yi XieJoseph W DePierre
Dec 18, 2002·Annals of the New York Academy of Sciences·Yi XieJoseph W DePierre
Apr 18, 2009·Molecular Endocrinology·Felix Grün, Bruce Blumberg
Apr 30, 2013·PloS One·Xiaobing TanZhanxiang Zhou
Feb 4, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Ricardo V García-MayorAnunciación Lafuente Giménez
Sep 8, 2010·International Immunopharmacology·Mousumi Rahman QaziManuchehr Abedi-Valugerdi
May 26, 2009·Toxicology·Mousumi Rahman QaziManuchehr Abedi-Valugerdi
Jun 5, 2015·Archives of Toxicology·Irina G ShabalinaJan Nedergaard
Jun 6, 2013·Biochimica Et Biophysica Acta·Shane M Regnier, Robert M Sargis
May 24, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Irina G ShabalinaJan Nedergaard
Jan 9, 2016·Epidemiology·Jessie P BuckleyAndrew G Rundle
Dec 2, 2015·PloS One·Anna MattssonBjörn Brunström
May 13, 2009·Molecular and Cellular Endocrinology·Felix Grün, Bruce Blumberg
May 13, 2009·Molecular and Cellular Endocrinology·Erin P HinesSuzanne E Fenton
Oct 25, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A M CardosoL Rato
Jun 13, 2015·Scientific Reports·Shengmin YanJiayin Dai
Aug 27, 2015·Environmental Health Perspectives·Jessie P BuckleyAmy H Herring
Apr 17, 2007·The British Journal of Nutrition·Pei-Min ChaoChing-Jang Huang
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
Jan 29, 2019·Frontiers in Physiology·Ilaria Di GregorioLillà Lionetti
Dec 13, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Tanja Schwerdtle
Nov 16, 2019·Chemosphere·Jasna BogdanskaStefan Nobel
Mar 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Jaclyn A JanisAbby F Fleisch