PMID: 8958934Oct 31, 1996Paper

Characterization of the adjuvant effect of IL-12 and efficacy of IL-12 inhibitors in type II collagen-induced arthritis

Annals of the New York Academy of Sciences
T GermannE Rüde

Abstract

A destructive joint disease can be induced in susceptible DBA/1 mice by immunization with type II collagen emulsified with oil and either killed Mycobacterium tuberculosis or IL-12 as adjuvant. Cellular and humoral anti-collagen immune mechanisms appear to be involved in the pathogenesis of arthritis. We have characterized the adjuvant effect or IL-12 in more detail and addressed the question whether mycobacteria might act via the induction of endogenous IL-12. Injections of IL-12 into collagen-immunized DBA/1 mice promoted the development of IFN-gamma-producing CD4+ T cells and strongly upregulated the production of complement-fixing IgG2a and IgG2b antibodies resulting in severe arthritis. Neutralization of IFN-gamma in vivo largely inhibited the increase in antibody synthesis and prevented joint disease in IL-12-treated mice. However, collagen-specific IFN-gamma synthesis by T cells was further enhanced in these animals. Furthermore, IL-12 treatment promoted the development of IFN-gamma-producing T cells but failed to enhance antibody synthesis and to induce arthritis in C57BL/6 or BALB/c mice immunized with collagen in oil. These results indicate that the induction (by IL-12) of a strong collagen-specific T-cell response al...Continue Reading

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Citations

Mar 17, 2001·Microbes and Infection·M C Braun, B L Kelsall
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E J JonesJohn A Kirby
Mar 6, 2004·Hybridoma and Hybridomics·Jiali LiAlan L Epstein
May 26, 2001·The Journal of Clinical Investigation·A NakajimaC G Fathman
May 4, 2007·The Journal of Clinical Investigation·Ilona Gutcher, Burkhard Becher
May 27, 2008·Journal of Autoimmunity·Valérie DardalhonAna C Anderson
Feb 12, 2010·Annals of the New York Academy of Sciences·Jesse M DamskerRachel R Caspi
Jul 30, 2005·The Journal of Surgical Research·Paula K Shireman, Marlon P Quinones
Feb 2, 2008·Arthritis and Rheumatism·J Claude Bennett
Jan 19, 2016·Current Opinion in Rheumatology·Karine CheminVivianne Malmström
Mar 8, 2006·Immunology and Cell Biology·Leilani L SantosEric F Morand
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·David D BrandEdward F Rosloniec
Nov 3, 2020·Journal of Cellular and Molecular Medicine·Seyed-Morteza EhteshamfarAmir Abbas Momtazi-Borojeni

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