PMID: 6292228Sep 1, 1982

Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment

Journal of Autonomic Pharmacology
V J LottiP Kling

Abstract

1 Low concentrations of isoprenaline (EC50 = 45.6 nM) inhibited contractions in the isolated field stimulated rat vas deferens. This inhibitory effect was markedly attenuated by the postjunctional beta 2-adrenoreceptor antagonist timolol, but not affected by the prejunctional alpha 2 or postjunctional alpha 1-adrenoreceptor antagonists rauwolscine and prazosin, respectively. 2 In vas deferens of rats previously treated with reserpine, the postjunctional beta 2-adrenoreceptor-mediated inhibitory response to isoprenaline was markedly potentiated. 3 High concentrations of isoprenaline (EC50 = 1.5 microM) also inhibited contractility in tissues in which postjunctional beta 2-adrenoreceptors were maximally blocked by high concentrations of timolol. This contractile inhibition produced by isoprenaline was abolished by rauwolscine but not significantly altered by prazosin or pretreatment of the rats with reserpine indicating stimulation of prejunctional alpha 2-adrenoreceptors. 4 Rauwolscine pretreatment unmasked an ability of isoprenaline (EC50 = 17.1 microM) to produce enhancement of field stimulation-induced contractions. This response was abolished by prazosin but was unaffected by timolol or reserpinization indicating an action u...Continue Reading

References

Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
May 1, 1977·British Journal of Pharmacology·J C DoxeyJ M Walker
Dec 1, 1977·British Journal of Pharmacology·D A JenkinsP A Nasmyth
Feb 1, 1977·British Journal of Pharmacology·R J Marshall, J R Parratt
Dec 5, 1980·European Journal of Pharmacology·V J LottiP Kling
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

Related Concepts

Novodrin
Pratsiol
August Rats
Norepinephrine Receptors
Alpha-adrenergic receptor
Beta-adrenergic receptor
V-Serp
Timoptol
Vas Deferens Structure
Yohimbin Spiegel

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.