PMID: 9557159Apr 29, 1998Paper

Characterization of the altered cutaneous reactivity of transgenic mice whose keratinocytes overexpress B7-1

Clinical Immunology and Immunopathology
A A GaspariR K Barth

Abstract

B7-1 (CD80) is a second signal molecule usually associated with "professional" APCs that prevents the induction of T-cell clonal anergy and induces IL-2 production during antigen presentation. Tg mice whose epidermal KC overexpress B7-1 exhibit exaggerated and persistent CHS to a variety of haptens that lasts up to 8 weeks after hapten challenge. These Tg mice also exhibit significantly enhanced ear-swelling responses to irritants that are not persistent. Exaggerated CHS was not reflected in the draining lymph node. T-lymphocyte proliferative responses after sensitization and local challenge with haptens, as there were no significant differences between the B7-1 Tg and the NTg mice. However, RT-PCR analysis of mouse ear skin at the hapten challenge site indicated that B7-1 Tg mice had an alteration in the kinetics of in situ lymphokine transcripts compared to NTg mice: IFN-gamma transcripts were first detectable in Tg mouse skin at 2 weeks versus 24 h for NTg mice. RNase protection assays to detect inflammatory cytokine transcripts at hapten application sites indicated that B7-1 Tg mice responded to hapten application with increased TNF-alpha, IL-6, and TNF-beta transcripts compared to NTg mice. Thus, hapten-induced ear swellin...Continue Reading

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Citations

Jun 4, 2004·Current Allergy and Asthma Reports·Clemens EscheLisa A Beck
Apr 17, 2009·The Journal of Investigative Dermatology·Adnan Nasir
Jun 9, 2000·The Journal of Investigative Dermatology·P WakemA A Gaspari
Apr 2, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·J B TraversD Y Leung
Jan 28, 2006·The Journal of Investigative Dermatology·Thomas H ThatcherAnthony A Gaspari
Jul 9, 2011·Anais Brasileiros De Dermatologia·Luis Eduardo Agner Machado Martins, Vitor Manoel Silva Dos Reis
Sep 15, 2017·Journal of Oral Science·Alison MarshallStephen Porter

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