Characterization of the anaemia associated with Graves' disease.

Clinical Endocrinology
Andrew G GianoukakisTerry J Smith

Abstract

Graves' disease (GD) is associated with hyperthyroidism. Thyrotoxicosis adversely affects multiple organ systems including haematopoiesis. Anaemia occurring specifically in GD has not been systematically studied previously. To define the prevalence and characteristics of the anaemia associated with GD. Eighty-seven newly diagnosed patients with GD were recruited. Haematological indices, thyroid function and inflammatory parameters were examined at presentation and following successful treatment of hyperthyroidism. Tertiary care academic referral centre. Thirty-three per cent of subjects presented with anaemia. The prevalence of anaemia not attributable to other causes (GD anaemia) was 22%. GD anaemia affected 41.6% (10/24) of men compared to 17.5% of women (11/63). Mean erythropoietin (EPO) levels (15.5 +/- 5.3 mIU/ml) were within normal reference limits but significantly higher (P = 0.004) than those of the non-anaemic controls. Hgb correlated inversely with EPO (P = 0.05) and CRP (P = 0.04) levels, a relationship that persisted after multivariate adjustment for TT3 or TT4. With antithyroid therapy for 16 +/- 6.3 weeks, Hgb levels normalized in 8 out of 9 subjects with GD anaemia (10.7 +/- 0.8 to 13.5 +/- 1.3 g/dl, P = 0.0001)...Continue Reading

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Citations

Dec 2, 2011·Journal of Thyroid Research·Mohamed Osama Hegazi, Sherif Ahmed
Mar 8, 2012·Lancet·Jayne A Franklyn, Kristien Boelaert
Feb 13, 2016·PloS One·Mikael LehtihetBo Angelin
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