Characterization of the antinociceptive effects of oxycodone in diabetic mice

European Journal of Pharmacology
Chihiro NozakiJ Kamei

Abstract

We investigated the antinociceptive efficacy of systemic and centrally injected oxycodone on thermal hyperalgesia in streptozotocin-induced diabetic mice. The antinociceptive response was assessed by recording the latency in the tail-flick test using the radiant heat from a 50-W projection bulb on the tail. The tail-flick latency in diabetic mice was significantly shorter than that in non-diabetic mice. Oral (p.o.) and i.t., but not i.c.v., administration of oxycodone prolonged the tail-flick latency in diabetic mice to a level that was considerably longer than the baseline latency in non-diabetic mice. However, morphine did not significantly inhibit the tail-flick response in diabetic mice. The antinociceptive effect of either p.o. or i.t. oxycodone in non-diabetic mice, but not in diabetic mice, was antagonized by pretreatment with a selective mu-opioid receptor antagonist, beta-funaltrexamine. In non-diabetic mice, pretreatment with a selective kappa-opioid receptor antagonist, nor-binaltorphimine, had no effect on the peak antinociceptive effect of either p.o. or i.t. oxycodone at 30 min after administration, however, it slightly but significantly reduced oxycodone-induced antinociception at 60 and 90 min after administrati...Continue Reading

References

Jan 1, 1984·Annals of Neurology·M J Brown, A K Asbury
Mar 18, 2000·European Journal of Pharmacology·J KameiH Nagase
Jun 30, 2001·European Journal of Pharmacology·J KameiS Tanaka
Nov 1, 2005·European Journal of Pharmacology·Chihiro NozakiJunzo Kamei

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Citations

May 5, 2010·Neurocritical Care·Yazmin Morales OdiaWendy C Ziai
Mar 8, 2013·Trends in Pharmacological Sciences·Klaus T OlkkolaEija A Kalso
Apr 13, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Kathleen J OttoMaree T Smith
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Jul 27, 2010·British Journal of Clinical Pharmacology·Anne Estrup OlesenAsbjørn Mohr Drewes
Sep 24, 2015·Journal of Biomedical Science·Pao-Pao YangPao-Luh Tao
Jul 10, 2016·European Journal of Pharmacology·Rachel M EngaPatrick M Beardsley
Aug 9, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pao-Pao YangPao-Luh Tao
Jun 9, 2016·Korean journal of anesthesiology·Byung Moon Choi
Mar 21, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael A EmeryShoshana Eitan
Feb 17, 2015·Expert Review of Neurotherapeutics·Joseph V PergolizziRobert B Raffa
Apr 25, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Graham MazereeuwDavid N Juurlink
Nov 28, 2020·Cellular and Molecular Neurobiology·Cherkaouia KibalyCatherine M Cahill

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