Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio)

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Daniela ZizioliPeter Schu

Abstract

Protein transport between the trans-Golgi network and endosomes is mediated by transport vesicles formed by the adaptor-protein complex AP-1, consisting of the adaptins γ1, β1, μ1, σ1. Mammalia express μ1A ubiquitously and isoform μ1B in polarized epithelia. Mouse γ1 or μ1A 'knock out's revealed that AP-1 is indispensable for embryonic development. We isolated μ1A and μ1B from Danio rerio. Analysis of μ1A and μ1B expression revealed tissue-specific expression for either one during embryogenesis and in adult tissues in contrast to their expression in mammalia. μ1B transcript was detected in organs of endodermal derivation and "knock-down" experiments gave rise to embryos defective in formation of intestine, liver, and pronephric ducts. Development ceased at 7-8 dpf. μ1B is not expressed in murine liver, indicating loss of μ1B expression and establishment of alternative sorting mechanisms during mammalian development.

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Citations

Apr 18, 2013·PloS One·Rachel Clemens GrishamTeresa Nicolson
Aug 26, 2014·Annual Review of Cell and Developmental Biology·Yusong GuoRandy Schekman
Nov 12, 2014·Membranes·Fubito NakatsuHiroshi Ohno
Jan 18, 2017·Cold Spring Harbor Perspectives in Biology·Lena Brüser, Sven Bogdan
Oct 15, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Giuseppina GarianoDaniela Zizioli
Jun 15, 2014·Journal of Cell Science·Jennifer BaltesPeter Schu

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