PMID: 16519320Mar 8, 2006Paper

Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations

Environmental Toxicology and Chemistry
Nirmal K RoyIsaac Wirgin

Abstract

Atlantic tomcod from the Hudson River, USA, are resistant to cytochrome P4501A1 (CYP1A1) mRNA induction and early life stage toxicities induced by coplanar polychlorinated biphenyls (PCBs) or tetrachlorodibenzo-p-dioxins but not polycyclic aromatic hydrocarbons. We sought to determine if basal expression or inducibility of aryl hydrocarbon receptor repressor (AHRR) mRNA is higher in tomcod from the resistant Hudson River population than in those from sensitive populations. Tomcod AHRR cDNA was characterized and its expression quantified in different tissues and life stages of tomcod from the Hudson River, Miramichi River, Canada (sensitive), and among environmentally exposed tomcod from these two sources and the St. Lawrence River, Canada. Phylogenetic analysis revealed that tomcod AHRR falls within the clade of other vertebrate aryl hydrocarbon receptors (AHRs) but is most closely related to the four previously identified AHRR genes. Induction of AHRR mRNA was observed in all tissues of PCB77-treated juvenile tomcod of Miramichi River descent, and expression differed among tissues and was significantly related to levels of CYPIAI mRNA expression. Aryl hydrocarbon receptor repressor mRNA was similarly inducible in F2 embryos of...Continue Reading

Citations

Dec 25, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sonya M BilliardRichard T Di Giulio
Apr 4, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anna L ZimmermannWade H Powell
Nov 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jin-Seon LeeHisato Iwata
Sep 16, 2006·Biological Chemistry·Thomas Haarmann-Stemmann, Josef Abel
Aug 19, 2015·Environmental Toxicology and Pharmacology·Viktoriia BurkinaGalia Zamaratskaia
Sep 25, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas Haarmann-StemmannEllen Fritsche

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