Characterization of the atherosclerotic plaque in the internal mammary artery

Catheterization and Cardiovascular Diagnosis
E ArciniegasA Bello

Abstract

The current study examines, at both structural and ultrastructural levels, representative segments of internal mammary arteries obtained from 15 male patients, ranging in age from 45 to 75 years, with signs or symptoms of coronary heart disease. These segments were obtained at the time of coronary bypass surgery. Of the 15 segments examined, only 2 were found to have atherosclerotic plaques. In other segments, only an intimal thickening similar to that observed during aging was found. There was evidence of endothelial cell loss and defects of internal elastic lamina in the present study; however, there was no evidence of lipid accumulation in the intimal region. This observation agrees with previous findings that indicate that lipid accumulation is not a necessary factor for the formation of atherosclerotic plaques. During the study microfilament bundles, the so-called "stress fibers," were also observed in the cytoplasm of the luminal side of endothelial cells. Stress fibers are known to be present in some endothelial cells in some pathologies such as regeneration after injury or hypertension. One of the features of the atherosclerotic plaques from an internal mammary artery was the presence of cells with contractile and synth...Continue Reading

References

Jan 1, 1979·Physiological Reviews·J Chamley-CampbellR Ross
Jun 11, 1976·The Annals of Thoracic Surgery·H R KayD Lepley
Jun 1, 1989·The Annals of Thoracic Surgery·T Sisto, J Isola
Apr 1, 1986·Circulation Research·S M SchwartzJ H Campbell
Jan 1, 1987·Differentiation; Research in Biological Diversity·U Hedin, J Thyberg
Apr 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K Chen, T N Wight
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G GabbianiS M Schwartz
Aug 1, 1983·The Journal of Cell Biology·G E WhiteK Fujiwara
Nov 1, 1981·Atherosclerosis·J H Chamley-Campbell, G R Campbell
Jul 1, 1995·Physiological Reviews·G K Owens
Sep 1, 1995·Circulation Research·S M SchwartzE R O'Brien

❮ Previous
Next ❯

Citations

May 2, 2009·Plastic and Reconstructive Surgery·Justin M Sacks, David W Chang
Jan 29, 2014·Ultrastructural Pathology·Ida PerrottaAlfonso Agnino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.