Characterization of the autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) as a model to study effects of castration therapy

The Prostate
Pernilla WikströmAnders Bergh

Abstract

In order to learn more about short- and long-term effects of castration therapy, relevant model systems for prostate cancer are required. In this study, we examined whether the transgenic adenocarcinoma of the mouse prostate (TRAMP) tumor response to castration in C57BL/6 mice mimics that seen in patients. Transgenic animals were examined before and 3 days after castration, at the ages of 17, 24, and 36 weeks. Moreover, 24-weeks old animals were castrated and followed for 6 months. Immunohistochemistry (IHC) and stereology were used to evaluate epithelial cell proliferation and death, blood vessel volume, androgen receptor (AR) expression, and transgenic expression of SV40 large T. Cancer developed preferentially in the dorso-lateral prostate lobe. Tumor burden and incidence of metastases increased with age. The majority of tumors were well differentiated, while poorly differentiated, large tumors and macroscopic metastases developed in 8% of the animals. Well and moderately differentiated tumors responded to castration with cessation of proliferation and induction of apoptosis. Poorly differentiated tumors and metastases did not respond. Castration prevented local tumor growth for at least 6 months in 82% of the cases. Althoug...Continue Reading

References

Mar 15, 1979·Nature·D P Lane, L V Crawford
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·F BladouP H Lange
Apr 30, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·N G ChoiT Y Jung
Jul 28, 1999·Urological Research·E LekåsJ E Damber
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·S GuptaH Mukhtar
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·J R GingrichN M Greenberg
Apr 15, 2003·The Prostate·Paula J Kaplan-LefkoNorman M Greenberg
Jul 30, 2003·The Prostate·Andrew B SmithermanJames L Mohler
Feb 3, 2004·Journal of Cellular Biochemistry·Mary-Ellen Taplin, Steven P Balk

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Citations

Jan 28, 2009·BMC Cancer·Curt E HarperCoral A Lamartiniere
Apr 4, 2012·PloS One·Eva KällbergTomas Leanderson
Apr 29, 2009·Asian Journal of Andrology·Zai-Xian ZhangXiao-Feng Wang
Nov 22, 2007·Neoplasia : an International Journal for Oncology Research·Wendy J HussGary J Smith
Jun 20, 2008·The Prostate·Christopher S OntiverosE Lynette Wilson
May 12, 2017·PloS One·Alexander B Opoku-AcheampongBrian L Lindshield
Jan 1, 2012·Cancers·Christina Hägglöf, Anders Bergh
Oct 12, 2007·The Prostate·Carlise R Bethel, Charles J Bieberich
May 14, 2017·Journal of Biomedical Science·Raquel Frenedoso da SilvaValéria Helena Alves Cagnon

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