PMID: 8589457Nov 1, 1995Paper

Characterization of the avian GLUT1 glucose transporter: differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts

Molecular Biology of the Cell
P WagstaffM K White

Abstract

Vertebrate cells that are transformed by oncogenes such as v-src or are stimulated by mitogens have increased rates of glucose uptake. In rodent cells, the mechanisms whereby glucose transport is up-regulated are well understood. Stimulation of glucose transport involves an elevation in mRNA encoding the GLUT1 glucose transporter that is controlled at the levels of both transcription and mRNA stability. Cloning and sequencing of chicken GLUT1 cDNA showed that it shares 95% amino acid sequence similarity to mammalian GLUT1s. Nevertheless, unlike mammalian GLUT1 mRNA, it was not induced by v-src, serum addition, or treatment with the tumor promoter 12-O-tetradecanoylphorbol 13-acetate in chicken embryo fibroblasts. Rather, the induction of glucose transport in chicken embryo fibroblasts by v-src, serum, and 12-O-tetradecanoylphorbol 13-acetate was associated with induction of GLUT3 mRNA level and GLUT3 transcription. Rat fibroblasts were also found to express both GLUT1 and GLUT3 isoforms, but v-src induced GLUT1 and not GLUT3. This suggests that animal cells require both a basal and an upregulatable glucose transporter and that these functions have been subsumed by different GLUT isoforms in avian and mammalian cells.

References

Jan 1, 1990·Trends in Biochemical Sciences·G W Gould, G I Bell
Jul 16, 1990·Biochemical and Biophysical Research Communications·T YamamotoH Imura
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A FrohmanG R Martin
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J CharronH F Lodish
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K H KaestnerM D Lane
Jul 13, 1989·Nature
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J BirnbaumO M Rosen
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H FukumotoG I Bell
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D W SalterM J Weber
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Feb 1, 1994·European Journal of Biochemistry·M Mueckler
Dec 1, 1993·Journal of Neurochemistry·S NagamatsuT Hoshino
Mar 1, 1994·International Journal of Cancer. Journal International Du Cancer·P MellanenP Härkönen

❮ Previous
Next ❯

Citations

Mar 2, 1999·Microvascular Research·P Dore-DuffyJ C LaManna
Aug 6, 2003·General and Comparative Endocrinology·Yoshinori SekiYukio Akiba
Jun 6, 2000·Brain Research. Developmental Brain Research·Y Ban, L J Rizzolo
Nov 25, 1997·Brain Research. Developmental Brain Research·L W EcksteinS N Pennington
Nov 25, 2000·Cancer Letters·M FukuzumiH Tanioka
Feb 5, 2003·The International Journal of Biochemistry & Cell Biology·Mira Grdisa, Martyn K White
Dec 5, 1998·The International Journal of Biochemistry & Cell Biology·M Grdisa
Jun 8, 1999·Molecular Biology of the Cell·E Penuel, G S Martin
Apr 2, 1998·European Journal of Cell Biology·R M JohnstoneM K White
Sep 9, 2005·Journal of Cellular Biochemistry·Hei Yi WongYuan Yuan Ho
Sep 17, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Brooke D HumphreyKirk C Klasing
May 30, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Karen L Sweazea, Eldon J Braun
Nov 25, 1998·Biochemical and Biophysical Research Communications·S E SteaneM K White
Apr 6, 2017·Microarrays·Mary Shannon ByersXiaofei Wang
Jun 20, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Min Young LeeHo Jae Han
Sep 29, 2000·FEBS Letters·J V PlanasJ Gutiérrez
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·C ReisserP Bannasch
Apr 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Encarnación CapillaJosep V Planas
Jan 24, 2007·The Journal of Nutrition·Shashidhara G Rudrappa, Brooke D Humphrey
Dec 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yung-Che TsengPung-Pung Hwang
Aug 30, 2014·Molecular Biology Reports·José A Martínez-QuintanaGloria Yepiz-Plascencia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
F M CarverS N Pennington
European Journal of Cell Biology
R M JohnstoneM K White
International Journal of Cancer. Journal International Du Cancer
P MellanenP Härkönen
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
A MathewR M Johnstone
© 2021 Meta ULC. All rights reserved