PMID: 6969527Jun 1, 1980Paper

Characterization of the bactericidal antibody response against Haemophilus influenzae

Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
T Dahlberg, P Branefors

Abstract

Rabbits were used in a study of the bactericidal (BC) antibody response against Haemophilus influenzae of types a and b and their respective non-capsulated variant strains. Previously described methods, complement fixation and indirect hemagglutination, were used for comparison. A bactericidal antibody response was demonstrable within a week after the primary immunization against capsulated as well as non-capsulated bacteria. After the hyperimmunization course the BC titres against noncapsulated bacteria were about 1:4,000, while the BC titres against the capsulated - type a and b-strains reached levels of no less than 1:30,000. Samples of separated hyperimmune sera showed BC activity in IgM- as well as IgG-containing fractions, whereas the BC activity of primary response samples was demonstrable mainly in IgM-containing fractions. The BC effect on non-capsulated bacteria of primary response samples were more heat labile than those obtained after hyperimmunization. In immune sera a crossreactive BC activity was demonstrable on non-capsulated bacteria, the titre being 32-64-fold lower than that of the homologous activity.

References

Dec 1, 1978·The Journal of Infectious Diseases·A R Flesher, R A Insel
Sep 1, 1978·CRC Critical Reviews in Microbiology·M Solotorovsky, M Lynn
Jul 1, 1973·The Journal of Infectious Diseases·D Rowley
Jan 1, 1972·The Journal of Clinical Investigation·P AndersonD H Smith
Jan 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·C W Norden
Jan 1, 1973·Clinical Immunology and Immunopathology·R B JohnstonD H Smith
Jan 31, 1932·The Journal of Experimental Medicine·H K Ward, J Wright

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.