Characterization of the canine type C enterotoxin produced by Staphylococcus intermedius pyoderma isolates.

Infection and Immunity
V M EdwardsG A Bohach

Abstract

The type C staphylococcal enterotoxins (SECs) are a group of highly conserved proteins with substantial antigenic cross-reactivity. Although Staphylococcus intermedius and coagulase-positive species of staphylococci are reported to produce SEC and other SEs, toxins produced by species other than Staphylococcus aureus have not been previously characterized. In this study we report the molecular, biological, and immunological properties of the canine SEC (SECcanine) expressed by pathogenic isolates of S. intermedius. The mature form of SECcanine has 239 amino acid residues and a pI of 7.0. Typical of the SEs, purified SECcanine induces an emetic response in monkeys and the proliferation of T cells in a Vbeta-dependent manner. Although SECcanine has >95% sequence identity to previously described SEC variants, its sequence is most related to SEC2 and SEC3. In contrast to the sequence similarity, the Vbeta profile induced by SECcanine is typical of that induced by SEC1. This result is likely explained by the conservation of a cysteine residue at position 26 in SECcanine; residues at this position have been previously shown to determine subtype-dependent differences in T-cell receptor interactions of other SEs. Overall, these results...Continue Reading

References

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Citations

Oct 13, 2001·Infection and Immunity·S U LeeG A Bohach
Apr 21, 2012·Veterinary Dermatology·Jeanette Bannoehr, Luca Guardabassi
Dec 24, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S BörjessonU Grönlund
Apr 6, 2002·The Journal of Biological Chemistry·Young-In ChiGregory A Bohach
Feb 9, 2005·The Journal of Veterinary Medical Science·Asako SasakiShigenobu Ootsuki
Mar 20, 2004·Veterinary Dermatology·Aiden P Foster
Nov 28, 2001·Applied and Environmental Microbiology·K BeckerG Peters
Jun 24, 2004·Canadian Journal of Microbiology·Katherine A SchmidtAmbrose Cheung
Apr 18, 2018·Frontiers in Microbiology·Emilie L FisherGordon Y C Cheung
Jul 6, 2018·Nature Reviews. Genetics·Samuel K SheppardJ Ross Fitzgerald
Sep 10, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Elena Gómez-SanzMyriam Zarazaga
Dec 3, 2021·PLoS Pathogens·Karen C CarrollLars F Westblade

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