PMID: 1204608Nov 1, 1975Paper

Characterization of the component, which controls the transformation between the kinetic forms of the b cytochromes

European Journal of Biochemistry
M Eisenbach, M Gutman

Abstract

1. In the presence of KCN and a saturating concentration of antimycin the reduction of the b-type cytochromes in submitochondrial particles is biphasic. This phenomenon was explained by suggesting the existence of two kinetic forms of cytochrome b:bA-the active form which was reduced in the rapid phase, and bS-the sluggish form which was reduced in the slow phase. The ratio between these forms and the transformation from one to other was controlled by the redox state of an unknown component, names "y", located between cytochromes b and c1. Pre-treatment with ascorbate plus N,N,N1,N1-tetramethyl-p-phenylenediamine transforms all the b-type cytochromes to their sluggish form, and the reduction by succinate follows slow monophasic kinetics. The name "dynamic control mechanism" was given to this mechanism [Eisenbach, M. & Gutman, M. (1975) Eur. J. Biochem. 52, 107-116] 2. Increasing concentrations of antimycin (0-2 nmol/mg) in the presence of KCN increased the fraction of the rapid phase of the reduction but did not affect the calculated absolute rates of the reduction. It is concluded that antimycin delays the reduction of "y" and thus permits the observation of the biphasic phenomen, but that it is not essential for the operation...Continue Reading

References

Mar 3, 1975·European Journal of Biochemistry·M Eisenbach, M Gutman
Jul 1, 1972·Archives of Biochemistry and Biophysics·D F WilsonM Koppelman
Dec 14, 1972·Biochimica Et Biophysica Acta·M K Wikström, J A Berden
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M ErecińskaP L Dutton
Jun 8, 1973·Biochemical and Biophysical Research Communications·A M Lambowitz, W D Bonner
Jul 1, 1971·Archives of Biochemistry and Biophysics·J S Rieske
Dec 7, 1971·Biochemistry·M GutmanT P Singer
Jun 27, 1970·Nature·E C SlaterH J Wegdam
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·H BaumS H Lipton

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Citations

Apr 1, 1981·Journal of Bioenergetics and Biomembranes·B L Trumpower
Oct 12, 1981·Biochimica Et Biophysica Acta·Y Z JinC L Tsou
Nov 1, 1976·Archives of Biochemistry and Biophysics·M ErecińskaY Miyata
Jan 25, 1982·FEBS Letters·P RiccioE Quagliariello
Jan 1, 1981·European Journal of Biochemistry·P RiccioE Quagliariello
Jan 6, 1977·Biochimica Et Biophysica Acta·G Van Ark, J A Berden
Dec 22, 1980·Biochimica Et Biophysica Acta·M Gutman
Aug 12, 1981·Biochimica Et Biophysica Acta·G Van ArkE C Slater
Dec 15, 1982·Biochimica Et Biophysica Acta·C L TsouY Z Jin
Oct 21, 1976·Journal of Theoretical Biology·P Mitchell

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