Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats

European Journal of Pharmacology
A MoránLuis San Román

Abstract

We evaluated the renal vascular effects of serotonin in Nomega-Nitro-l-arginine-hypertensive rats (L-NAME, 30 mg/kg/day, administered over 21 days in drinking water), a model of systemic hypertension with glomerular capillary hypertension and renal disease due to chronic blockade of endogenous synthesis of nitric oxide (NO) and compared with those obtained in normotensive rats. Using several agonists and antagonists of 5-hydroxytryptamine (5-HT), we characterized the receptor subtypes involved in the contractile response to 5-HT in the in-situ autoperfused rat kidney. An intra-arterial (i.a.) bolus injection of 5-HT (0.00000125-0.1 microg/kg) increased renal perfusion pressure in a dose-dependent manner, but did not affect systemic blood pressure. The selective 5-HT(2) receptor agonist alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT) caused a local vasoconstrictor effect in the autoperfused rat kidney. The selective 5-HT(2B) receptor agonist BW723C86, the non-selective 5-HT(2C) receptor agonist (1-(3-chlorophenyl) piperazine), m-CPP, the 5-HT(1) receptor agonist 5-carboxamidotryptamine (5-CT) and the selective 5-HT(3) receptor agonist (1-(m-chlorophenyl)-biguanide), m-CPBG, did not modify renal perfusion pressure. The vasoc...Continue Reading

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Citations

Apr 10, 2015·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaA Morán
May 25, 2015·Vascular Pharmacology·José-Ángel García-PedrazaA Morán
Jan 31, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Ángel García-PedrazaA Morán
Feb 6, 2017·Scientific Reports·José Luis Miguel-CarrascoSusana Ravassa
Apr 29, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Gagandeep Kaur, Pawan Krishan

Related Concepts

Anesthesia Procedures
Diastolic Blood Pressure
Hypertensive Disease
Kidney
Perfusion
Receptors, Tryptamine
Serotonin Antagonists
Vascular Constriction (Function)
Rats, Wistar
Serotonin Agonists

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