Characterization of the developmental toxicity of Caribbean ciguatoxins in finfish embryos

Toxicon : Official Journal of the International Society on Toxinology
Jamie R ColmanJohn S Ramsdell

Abstract

Since oviparous fishes mobilize fat stores to produce eggs, we investigated the potential for deposition of gonadal ciguatoxins to the oil laden yolk sacs which nourish developing embryos, and characterized the effects of these toxins on finfish development. Results showed that ciguatoxins are more concentrated in the egg mass (0.18 ng/g) of a toxic fish than in the muscle (<0.04 ng/g). We used a microinjection technique in a Japanese medaka (Oryzias latipes) developmental fish model to mimic the maternal route of toxin exposure to finfish embryos. We describe the developmental effects of two preparations isolated from Caribbean great barracuda (Sphyraena barracuda): a highly purified toxin (C-CTX-1), and ciguatoxins extracted from the flesh of a toxic fish. C-CTX-1 induced a significant decrease in heart rate after four days, which did not persist with further development. Crude extracts from ciguatoxic fish flesh induced hyperkinetic twitching and severe spinal deformities. These effects were observed in embryos receiving as little as 5 pg/egg, and were consistently found in embryos receiving doses exceeding 10 pg/egg. The occurrence of twitching and spinal deformities increased in both frequency and severity with dose. Larva...Continue Reading

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Citations

Sep 29, 2009·Toxicon : Official Journal of the International Society on Toxinology·Robert W Dickey, Steven M Plakas
Sep 16, 2006·Toxicon : Official Journal of the International Society on Toxinology·Marie-Yasmine Bottein DechraouiJohn S Ramsdell
Oct 6, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·John P BerryMichael C Schmale
Aug 18, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Shosaku KashiwadaDavid E Hinton
Aug 3, 2005·Neurotoxicology and Teratology·Jessica A TiedekenAnn F Ramsdell
Jun 29, 2005·Toxicon : Official Journal of the International Society on Toxinology·M-Yasmine Bottein DechraouiJohn S Ramsdell
May 21, 2005·Toxicon : Official Journal of the International Society on Toxinology·Jamie R ColmanJohn S Ramsdell
Jul 21, 2017·Marine Drugs·Yuri B Shmukler, Denis A Nikishin
May 2, 2018·Environmental Toxicology and Chemistry·Christopher R LoefflerDavid Olsen
Nov 12, 2009·Journal of Food Protection·Cheng-Hong HsiehDeng-Fwu Hwang
Jan 23, 2021·Animals : an Open Access Journal From MDPI·Andres Sanchez-HenaoFernando Real
Aug 27, 2021·Toxins·Isabel do Prado LeiteMarie-Yasmine Dechraoui Bottein

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