Abstract
Nociceptin/orphanin FQ receptor (NOP) agonists have been reported to produce antinociceptive effects in rhesus monkeys with comparable efficacy to μ-opioid receptor (MOP) agonists, but without their limiting side effects. There are also known to be species differences between rodents and nonhuman primates (NHPs) in the behavioral effects of NOP agonists. The aims of this study were the following: 1) to determine if the NOP agonist Ro 64-6198 could be trained as a discriminative stimulus; 2) to evaluate its pharmacological selectivity as a discriminative stimulus; and 3) to establish the order of potency with which Ro 64-6198 produces discriminative stimulus effects compared with analgesic effects in NHPs. Two groups of rhesus monkeys were trained to discriminate either fentanyl or Ro 64-6198 from vehicle. Four monkeys were trained in the warm-water tail-withdrawal procedure to measure antinociception. Ro 64-6198 produced discriminative stimulus effects that were blocked by the NOP antagonist J-113397 and not by naltrexone. The discriminative stimulus effects of Ro 64-6198 partially generalized to diazepam, but not to fentanyl, SNC 80, ketocyclazocine, buprenorphine, phencyclidine, or chlorpromazine. Fentanyl produced stimulus e...Continue Reading
References
Mar 1, 1978·Pharmacology, Biochemistry, and Behavior·J A Goas, J E Boston
Jan 1, 1992·Psychopharmacology·C P FranceJ H Woods
Dec 1, 1982·Neuropharmacology·R E SolomonJ H Woods
Nov 3, 1995·Science·R K ReinscheidO Civelli
Oct 12, 1995·Nature·J C MeunierB Monsarrat
Mar 14, 1994·FEBS Letters·C MollereauJ C Meunier
Apr 11, 1997·European Journal of Pharmacology·T SuzukiH Nagase
Jul 16, 1997·European Journal of Pharmacology·T SuzukiH Nagase
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·F C Colpaert
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·F JenckG Kilpatrick
Sep 28, 2000·European Journal of Medicinal Chemistry·J WichmannF Jenck
Jul 11, 2001·Neuropharmacology·G A HigginsJ Wichmann
Oct 15, 2003·The Journal of Pharmacology and Experimental Therapeutics·Glenn W StevensonS Stevens Negus
Jul 1, 2004·The Journal of Pharmacology and Experimental Therapeutics·Matthew D Recker, Guy A Higgins
Jul 19, 2005·Psychopharmacology·G B VartyG A Higgins
Aug 2, 2008·Nature Reviews. Drug Discovery·David G Lambert
Feb 24, 2009·The Journal of Pain : Official Journal of the American Pain Society·Mei-Chuan Ko, Norah N Naughton
Mar 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mei-Chuan KoEric P Prinssen
Sep 21, 2010·Psychopharmacology·Christopher A PodlesnikJames H Woods
Jan 18, 2012·Psychopharmacology·Celia GoeldnerEric P Prinssen
Jun 30, 2012·The Journal of Pharmacology and Experimental Therapeutics·Colette M CremeansMei-Chuan Ko
Nov 13, 2013·Psychopharmacology·Devki D SukhtankarMei-Chuan Ko
Apr 26, 2014·British Journal of Pharmacology·W SchröderT Koch
Jun 28, 2014·Pain·Brian D Kangas, Jack Bergman
Citations
Mar 28, 2018·British Journal of Pharmacology·Akihiko OzawaLawrence Toll
May 23, 2017·ILAR Journal·Matthew L BanksSidney S Negus
Oct 5, 2018·Frontiers in Psychiatry·Vinod KumarStephen M Husbands
Jun 1, 2021·CNS Drugs·Lawrence TollAkihiko Ozawa