Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies

Circulation
C M OttoK D O'Brien

Abstract

Nonrheumatic stenosis of trileaflet aortic valves, often termed senile or calcific valvular aortic stenosis, is considered a "degenerative" process, but little is known about the cellular or molecular factors that mediate its development. To characterize the developing aortic valvular lesion, we performed histological and immunohistochemical studies on Formalin-fixed and methanol-Carnoy's-fixed paraffin-embedded aortic valve leaflets or on frozen sections obtained at autopsy from 27 adults (age, 46 to 82 years) with normal leaflets (n = 6), mild macroscopic leaflet thickening (n = 15), or clinical aortic stenosis (n = 6). Focal areas of thickening ("early lesions") were characterized by (1) subendothelial thickening on the aortic side of the leaflet, between the basement membrane (PAS-positive) and elastic lamina (Verhoeff-van Gieson), (2) the presence of large amounts of intracellular and extracellular neutral lipids (oil red O) and fine, stippled mineralization (von Kossa), and (3) disruption of the basement membrane overlying the lesion. Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation. Control valves showed none of these abnormalities. Immunohi...Continue Reading

References

Sep 1, 1978·Journal of Gerontology·A PomeranceH M Hodkinson
Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S KatsudaI Nakanishi
Sep 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P E Knapp
Apr 1, 1990·Journal of the American College of Cardiology·J M IsnerG A Slovenkai
Sep 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T M BocanJ R Guyton
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M RathU Beisiegel
Feb 1, 1989·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·T L YearwoodK B Chandran
May 1, 1987·The American Journal of Medicine·S A StrickbergerG M Hutchins
Jan 1, 1987·Nephron·E R MaherJ R Curtis
Sep 1, 1986·The American Journal of Cardiology·W C Roberts
Oct 1, 1986·The Annals of Thoracic Surgery·M J ThubrikarJ D Deck
Nov 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T TsukadaA M Gown
Oct 1, 1986·Cardiovascular Research·J D Deck
Mar 1, 1985·The American Journal of Cardiology·P M HoaglandL Goldman
Sep 1, 1965·British Heart Journal·A Pomerance
Jan 1, 1984·Journal of Chronic Diseases·S DeutscherV Krishnaswami
Sep 1, 1981·The American Journal of Medicine·W C Roberts, B F Waller
Jan 1, 1980·Journal of Biomechanics·A A SaurenF E Veldpaus
Jan 1, 1994·The Medical Clinics of North America·K D O'Brien, A Chait
Aug 1, 1993·Journal of the American College of Cardiology·A JosephJ Kupersmith
Feb 1, 1993·The American Journal of Cardiology·S BeppuK Miyatake
Mar 1, 1993·Medicinal Research Reviews·R L JacksonC E Thomas
Apr 1, 1993·Journal of the American College of Cardiology·M LindroosR Tilvis

❮ Previous
Next ❯

Citations

May 23, 2002·Clinical Cardiology·C Richard Conti
Jan 19, 2007·Current Atherosclerosis Reports·Dominique BeaudryRobert Chilton
Mar 21, 2009·Cell and Tissue Research·Manuela Voinea CalinMaya Simionescu
Mar 19, 2011·Biomechanics and Modeling in Mechanobiology·Choon Hwai YapAjit P Yoganathan
Feb 2, 2012·Biomechanics and Modeling in Mechanobiology·Santanu ChandraPhilippe Sucosky
May 27, 2005·The International Journal of Cardiovascular Imaging·Lawrence M Boxt
Jul 16, 2008·Journal of Thrombosis and Thrombolysis·Omer AlyanErdogan Ilkay
Jan 12, 2013·International Journal of Computer Assisted Radiology and Surgery·Zhe LuoLixu Gu
Dec 12, 2012·General Thoracic and Cardiovascular Surgery·Hirofumi Takemura
Aug 6, 2013·Current Atherosclerosis Reports·Catherine Martel, Gwendalyn J Randolph
Jan 29, 2008·Current Treatment Options in Cardiovascular Medicine·Matthew L Steinhauser, Peter H Stone
Mar 8, 2008·Current Treatment Options in Cardiovascular Medicine·Kameswari Maganti, Nalini Rajamannan
Sep 11, 2012·Current Treatment Options in Cardiovascular Medicine·Dina M Sparano, R Parker Ward
Jun 1, 2005·International Journal of Cardiology·Humberto PierriMauricio Wajngarten
Jan 22, 2004·Journal of Molecular and Cellular Cardiology·Z Mallat, A Tedgui
Sep 21, 2001·The American Journal of Cardiology·K L ChanI G Burwash
Oct 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Tirone E David, Joan Ivanov
Oct 5, 2001·Journal of the American College of Cardiology·A GalanteC Favalli
Jan 5, 2002·Journal of the American College of Cardiology·Jari SattaYlermi Soini
Nov 26, 2002·Journal of the American College of Cardiology·Michael F BellamyMaurice Enriquez-Sarano
Aug 23, 2003·Journal of the American College of Cardiology·Kwan-Leung Chan
Mar 1, 1997·Journal of the American College of Cardiology·B F StewartC M Otto
Apr 1, 1997·Journal of the American College of Cardiology·J JuvonenP Saikku
Nov 7, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M E EdepD L Brown
Apr 6, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Adam D Durbin, Avrum I Gotlieb
Oct 19, 2002·Academic Radiology·Matthew J BudoffKevin D O'Brien
Mar 21, 2002·Clinical Genetics·S D AvakianA P Mansura
Apr 26, 2007·Nature Clinical Practice. Cardiovascular Medicine·Nalini M RajamannanShahbudin H Rahimtoola
Sep 19, 2006·Nature Medicine·Masatoyo YoshiokaKeiichi Fukuda
Feb 14, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Christopher MoraesCraig A Simmons
Jul 4, 2012·Biologie aujourd'hui·Najlah KochtebaneMarie-Paule Jacob
Jul 3, 1997·The New England Journal of Medicine·B A Carabello, F A Crawford
Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.