Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation and soluble transferrin receptor

Leukemia
S J BradaE Vellenga

Abstract

In refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS) a discrepancy is observed between the decreased in vitro erythroid colony formation and the normal or increased number of normoblasts in the bone marrow. To study the in vivo and in vitro erythropoiesis in more detail erythron transferrin uptake (ETU), soluble transferrin receptor (sTfR) and erythroid in vitro colony formation were performed in 24 patients with RA and five patients with RARS. These results were correlated with bone marrow morphology and transfusion dependency. Increased (mean, 124.9; range, 74-225 micromol/l blood/day) and normal (mean, 60.6; range, 50-71) ETU values were observed in 51% and 28% of the cases, whereas 21% of the cases demonstrated a diminished ETU value (mean, 35.8; range, 28-46), which correlated significantly with sTfR in cases with RA (P < 0.05, r = 0.64). A significant difference in ETU values was observed between RA (mean, 77.6; range, 28-189) and RARS (mean, 144.0; range, 59-225, P < 0.05). Most of the cases (73%) with increased ETU values showed an augmented percentage of erythroblasts in the bone marrow, which was inversely related with the serum Epo levels (P < 0.05, r = 0.51). However no correlation was fou...Continue Reading

Citations

Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yves Beguin
Mar 14, 2000·Medical Oncology·A A van de Loosdrecht, E Vellenga
Dec 19, 2006·Journal of Immunological Methods·Joyce O P CheungSuzanne M Watt
Feb 20, 2008·Current Topics in Developmental Biology·Kathleen McGrath, James Palis
Jul 12, 2019·Science Translational Medicine·Sabrina BonduMichaëla Fontenay

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