Characterization of the Esophageal Microbiota and Prediction of the Metabolic Pathways Involved in Esophageal Cancer.

Frontiers in Cellular and Infection Microbiology
Donghang LiQing Geng

Abstract

Esophageal microbiota plays important roles in esophageal cancer. Esophagectomy, as the most important therapeutic way, contributes to changes of esophageal microbiome. However, there are few studies examining the esophageal microbiome and the metabolic changes before and after esophagectomy. The present study characterized the esophageal microbiome of 17 patients with esophageal squamous cell carcinoma (ESCC), 11 patients with esophagogastric junction (EGJ) cancer, 15 patients at 9-12 months after radical esophagectomy and 16 healthy controls (HC). 16S ribosomal RNA gene sequencing was used to evaluate the microbiome and predict the metabolic pathways. Our results showed that the microbial diversity was significantly lower in ESCC, EGJ and post-ESCC groups than that in the HC group. The abundance of Fusobacteria was higher (7.01 vs. 1.12%, P = 0.039) and the abundance of Actinobacteria (1.61 vs. 4.04%) was lower in the ESCC group than that in the HC group. We found significant differences in the abundance of Bacteroidetes (20.45 vs. 9.86%, P = 0.026), Fusobacteria (7.01 vs. 1.66%, P = 0.030) between ESCC and post-ESCC groups. The results of microbial composition analysis and PICRUSt demonstrated significant differences between...Continue Reading

References

Jun 18, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hongyu WuSusan S Devesa
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yiorgos ApidianakisLaurence Rahme
Jan 15, 2010·FEMS Microbiology Reviews·Jin-Hyung Lee, Jintae Lee
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Sep 10, 2011·Bioinformatics·Tanja Magoč, Steven L Salzberg
Oct 20, 2011·Genome Research·Mauro CastellarinRobert A Holt
Aug 27, 2013·Nature Biotechnology·Morgan G I LangilleCurtis Huttenhower
Jan 17, 2014·Frontiers in Cellular and Infection Microbiology·Panayiota Markou, Yiorgos Apidianakis
Feb 25, 2014·Gastroenterology·Max NieuwdorpLee M Kaplan
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Apr 5, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Guoqin YuChristian C Abnet
May 24, 2014·The Cancer Journal·Kyle M BrawnerPhillip D Smith
Oct 2, 2014·BMC Microbiology·Kai BaoNagihan Bostanci
Jan 15, 2015·Nucleic Acids Research·Melanie SchirmerChristopher Quince
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
May 28, 2016·Nature Reviews. Immunology·Michelle G Rooks, Wendy S Garrett
Oct 28, 2016·Annals of the New York Academy of Sciences·Vincenzo Di PilatoPaolo Bechi
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kensuke YamamuraHideo Baba
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Daffolyn R Fels ElliottRebecca C Fitzgerald
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Gerardo NardoneAlba Rocco
Jun 27, 2017·Lancet·Jesper LagergrenPernilla Lagergren
Aug 12, 2017·Science·Patrice D Cani
Nov 23, 2017·Scientific Reports·Natalia Castaño-RodríguezNadeem O Kaakoush
Dec 3, 2017·Cancer Research·Brandilyn A PetersJiyoung Ahn
Apr 10, 2018·Journal of Dental Research·M PereraN W Johnson
Jul 4, 2018·Journal of Gastroenterology and Hepatology·Xiaoke DiXinchen Sun
Oct 24, 2018·International Journal of Cancer. Journal International Du Cancer·J FerlayF Bray

❮ Previous
Next ❯

Citations

May 27, 2021·Applied Microbiology and Biotechnology·Changchang ChenJianxin Lyu
May 31, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ziyu JiangJiege Huo
Aug 28, 2021·Microorganisms·Yukiko YanoChristian C Abnet
Sep 11, 2021·Zeitschrift für Gastroenterologie·Andreas TeufelMatthias Philip Ebert
Sep 11, 2021·Cellular and Molecular Gastroenterology and Hepatology·Annemieke SmetJan Bornschein

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA628659

Methods Mentioned

BETA
PCR
biopsy
xenografts

Software Mentioned

PICRUSt
Trimmomatic
LEfSe
PICRUSt )
UPARSE
Multiple Experiment Viewer
ANOSIM
FLASH
MOTHUR
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Cell and Developmental Biology
Weixiong YangChao Cheng
Nihon rinsho. Japanese journal of clinical medicine
Satoshi NaraToshiro Konishi
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Hui LiKe-neng Chen
© 2021 Meta ULC. All rights reserved