Characterization of the expression, localization, and secretion of PANDER in alpha-cells.

Molecular and Cellular Endocrinology
Jason R CarnegieBrant R Burkhardt

Abstract

The novel islet-specific protein PANcreatic DERived Factor (PANDER; FAM3B) has been extensively characterized with respect to the beta-cell, and these studies suggest a potential function for PANDER in the regulation of glucose homeostasis. Little is known regarding PANDER in pancreatic -cells, which are critically involved in maintaining euglycemia. Here we present the first report elucidating the expression and regulation of PANDER within the alpha-cell. Pander mRNA and protein are detected in alpha-cells, with primary localization to a glucagon-negative granular cytosolic compartment. PANDER secretion from alpha-cells is nutritionally and hormonally regulated by l-arginine and insulin, demonstrating similarities and differences with glucagon. Signaling via the insulin receptor (IR) through the PI3K and Akt/PKB node is required for insulin-stimulated PANDER release. The separate localization of PANDER and glucagon is consistent with their differential regulation, and the effect of insulin suggests a paracrine/endocrine effect on PANDER release. This provides further insight into the potential glucose-regulatory role of PANDER.

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Citations

Nov 30, 2010·International Journal of Endocrinology·Chunjiong WangJichun Yang
Jan 29, 2014·The Journal of Endocrinology·Claudia E Robert-CoopermanBrant R Burkhardt
Nov 29, 2013·International Journal of Cell Biology·Serena BonomiClaudia Ghigna
Dec 19, 2012·The International Journal of Biochemistry & Cell Biology·Haiwei MouYingying Le
Jun 15, 2011·FEBS Letters·Camella G WilsonBrant R Burkhardt
Nov 30, 2018·Journal of Cellular and Molecular Medicine·Yujing ChiJichun Yang
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Jichun Yang, Youfei Guan
Sep 14, 2014·Disease Models & Mechanisms·Shari L MoakBrant R Burkhardt

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